Autorentext

Kuldeep Vinchurkar, PhD, works in the Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, affiliated to Savitribai Phule Pune University, Nashik, Maharashtra, India with more than 11 years of research and teaching experience. He has published five books, seven patents, and more than 30 research and review publications in national and international journals. His research interests include 3D printing, artificial intelligence, and novel drug delivery systems, especially gastroretentive drug delivery. Sheetal Mane, PhD is an Assistant Professor of Pharmaceutics at NMT Gujarati College of Pharmacy, Indore, Madhya Pradesh, India and has more than nine years of experience. She has published eight book chapters and 17 research papers in reputed journals and conferences. Her research focuses on novel drug delivery systems. Dinesh Kumar Mishra, PhD is a Professor in the Department of Pharmacy at Guru Ghasidas Vishwavidyalaya with more than 20 years of experience in teaching, research, and administration. He holds three national patents and has authored five books, ten chapters, and more than 80 publications in peer-reviewed national and international journals. He specializes in novel drug delivery systems, particularly lipid-based nanocarriers, transdermal drug delivery, vaccines, and product development.

Klappentext

This book provides a roadmap for creating customized, precision drug delivery systems and advancing personalized medicine by introducing the revolutionary, transformative role of 3D printing technology in medicine. The convergence of advanced manufacturing techniques with the complexities of pharmaceutical formulation has opened new frontiers of innovation, enabling unprecedented precision in drug delivery, tailored therapies, and complex dosage designs. From the creation of personalized drug formulations designed to meet the specific needs of individual patients to the development of complex, multi-functional drug delivery systems, the chapters within this volume explore a wide array of applications. This book is a groundbreaking resource that delves into the transformative role of 3D printing technology in the pharmaceutical field. Offering insights into customized and precision drug delivery systems, it highlights the synergy between advanced manufacturing techniques and pharmaceutical sciences. The book provides a balanced blend of theory and practical applications, presenting a roadmap for researchers and professionals to integrate 3D printing into their pharmaceutical processes. It discusses the role of innovative materials, cutting-edge technologies, and regulatory perspectives while highlighting the challenges and future trends in the field. By offering contributions from distinguished experts, the book serves as a comprehensive reference for understanding the potential of 3D printing to revolutionize drug delivery and advance personalized medicine. Readers will find this volume:

• Explores cutting-edge 3D printing applications in pharmaceutical sciences, emphasizing precision and innovation;
• Covers practical and theoretical insights into customized drug delivery systems using 3D printing;
• Includes detailed case studies and emerging trends for academic and industrial professionals;

• Features contributions from leading experts and researchers in the field. Audience Pharmaceutical scientists, academics, industrial researchers, formulation chemists, biotechnology professionals, and students specializing in pharmaceutical technology, drug delivery systems, and biopharmaceuticals.

  Inhalt

  Preface xxiii

  Part I: Fundamentals of 3D Printing in Pharmaceuticals 1

  1 Introduction to 3D Printing in Pharmaceuticals 3
  Sachin Joshi, Priya Jindal, Balak Das Kurmi, Manish Kumar and Kuldeep Vinchurkar

  1.1 Introduction 4
  1.2 Categories of 3D Printing Methods in Drug Delivery 6
  1.3 3D printing Materials Utilized for Pharmaceuticals 9
  1.4 Drug Delivery Technology in 3D Printing 11
  1.5 Various Applications of 3D Printing 14
  1.6 Possibilities and Difficulties Associated with Applying 3D Printing to Medicine 17
  1.7 Conclusion and Recommendations for the Future 18

  2 Fundamentals of Pharmaceutical 3D Printing 23
  Hardik Rana, Mansi Dholakia, Vimal Patel, Saloni Dalwadi and Kuldeep Vinchurkar

  2.1 Design to Object 24
  2.2 Types of 3D Printing Material 63
  2.3 Key Components of a 3D Printer 68
  2.4 Software and Tools for 3D Printing 82

  3 Advancements and Applications of 3D Bioprinting in Pharmaceutical Research: A Comprehensive Review 105
  Amar Deshpande, Shilpa S. Borkar, Ketki Bhatt, Koustubha S. Pachkor, Satish Polshetttiwar and Jagdish Baheti

  3.1 Introduction 106
  3.2 Classification of 3D Bioprinting (3DBP) 107
  3.3 Methods for Bioprinting 108
  3.4 Inkjet-Based Bioprinting 111
  3.5 Bioprinting Material 115
  3.6 Applications 118
  3.7 Advantages 119
  3.8 Disadvantages 119
  3.9 Future Prospective 120
  3.10 Conclusion 120

  4 3D Printing of Solid Dosage Forms 129
  Ashwin Kuchekar, Prajakta Wagh, Harshavardhan Karnik and Ashwini Gawade

  4.1 Introduction 130
  4.2 Types of 3D Printing Technologies for Solid Dosage Forms 133
  4.3 Materials Used in 3D Printing of Solid Dosage Forms 139
  4.4 Design and Formulation Considerations in 3D Printing of Oral Solid Dosage Forms 142
  4.5 Manufacturing Process 144
  4.6 Quality Control and Regulatory Aspects 151
  4.7 Case Studies and Applications 160
  4.8 Advantages of 3D Printing in Healthcare Industry 163
  4.9 Future Directions and Innovations in 3D Printing for Pharmaceuticals 165
  4.10 Conclusion 167

  Part II: Applications of 3D Printing in Pharmaceuticals 175

  5 3D Printing of Controlled Release Systems 177
  Chirag Jain, Shubham Kumar, Shreya Kaul, Manisha Pandey, Bapi Gorain, Najwa Mohamad and Neha Jain

  5.1 Introduction 178
  5.2 Technologies Utilized in 3D Printing 181
  5.3 Recent Advances in 3D Printing of Controlled Release Systems 183
  5.4 Technology Lab to Market 193
  5.5 Conclusion 200

  6 Fabrication of Implants and Medical Devices via Three-Dimensional Printing Technology 207
  Ruchira Srivastava and Ayushi Thakur

  6.1 Introduction 207
  6.2 Various Categories of Three-Dimensional Printing Techniques 209
  6.3 Applications in Medical Devices and Implants 217
  6.4 Advantages: 3D Printing in Medical Applications 222
  6.5 Challenges and Considerations of 3D Printing in Medical Applications 223
  6.6 Conclusion 224

  7 3D Printing in Drug Delivery System 229
  Satish Polshettiwar, Shrikant Dargude, Pranali Polshettiwar, Saloni Ghodmare, Swati Jagdale and Kuldeep Vinchurkar

  7.1 Introduction 230
  7.2 3D-Printed Drug Delivery System 232
  7.3 Applications of 3D Printing in Drug Delivery 245
  7.4 Challenges and Limitations 247
  7.5 Conclusion 248

  8 3D Bioprinting in Pharmaceutical Research 257
  Vijaya Padwal, Sachin Kothawade, Sandesh Bole and Kuldeep Vinchurkar

  8.1 Introduction 258
  8.2 Significance in Pharmaceutical Research 259
  8.3 Objectives and Structure 261
  8.4 Principles of 3D Bioprinting 262
  8.5 Types of Bioprinting 264
  8.6 Types of 3D Bioprinters 269
  8.7 Materials Used for Bioprinting 273
  8.8 Drug Evaluation 279
  8.9 Drug Delivery 280
  8.10 Customization of Patient-Specific Medications/Personalized Medicine 282
  8.11 3D Printing Method and Techniques 283
  8.12 Applications of 3D Printing in Personalized Medicines 284
  8.13 Conclusion 286

  9 Case Studies and Success Stories of Companies Leveraging 3D Printing Technology 295
  Debarshi Kar Mahapatra, Kuldeep Vinchurkar and Dinesh Kumar Mishra

  9.1 Introduction 296
  9.2 Technology and Future 298
  9.3 Case and Success Studies of Companies Leveraging 3D Printing Technology 300
  9.4 Conclusion 319

  Part III: Regulatory, Commercial, and Sustainability Aspects 323

  **10 Regulatory and Quality Considerations i…