The mammalian target of rapamycin (mTOR) is a central node in cell regulation, impacting everything from cellular growth and metabolism to the intricate mechanisms of aging and disease. Its role in the eye, however, is an emerging field that promises to revolutionize our understanding of ocular health and disease.

This book discusses the role of mTOR signaling in the eye. It aims bridge the gap between deep molecular biology and clinical ophthalmology by focusing on the profound effects of mTOR signaling in various parts of the eye. The initial chapters of this book lay the foundational knowledge necessary to understand the complex biology of mTOR, followed by the specific effects on each individual parts of the eye.

This book is written for researchers, clinicians, and students who are part of a multidisciplinary team striving to push the boundaries of ocular research into mTOR pathways. By the end of this journey, readers will have a comprehensive understanding of the multifaceted roles of mTOR in the eye and the brain, equipped with the knowledge to translate these insights into innovative treatments for ocular and neurodegenerative diseases.

The first book to discuss the role of mTOR signaling in the eye Offers a comprehensive overview of the biology of mTOR as well as the clinical implications Discusses potential new frontiers in the field of eye disease

Autorentext

Dr. Kambiz Thomas Moazed, MD, is a board certified ophthalmologist with over 40 years of surgical experience in NYC. At present he is an active surgical attending at Manhattan Eye and Ear and Throat Hospital of Lenox Hill. After graduation from medical school, Dr. Moazed completed a year of research fellowship in eye pathology at Stanford University's Department of Ophthalmology. He then completed a year of residency in general surgery at the Stanford Medical Center. He then followed his interest in Ophthalmology and completed another year of fellowship in eye pathology at Harvard Medical School's Massachusetts Eye and Ear Infirmary under Dr. Daniel Albert. He completed his Ophthalmology residency program at Harvard in 1982. Dr. Moazed became affiliated with Columbia University in New York City, where he served as Associate Clinical Professor, teaching residents at the St. Luke's Roosevelt Hospital Centers for 25 years. He also served as the Director of Oculo-Plastic Surgery and Orbital Surgery at Harlem Hospital under the Columbia University affiliation for 15 years.

Inhalt

Chapter 1. Molecular Biology of mTOR.- Chapter 2. mTOR Signaling Pathways.- Chapter 3. mTOR Effect on Eye Embryology.- Chapter 4. mTOR Effect on Conjunctiva.- Chapter 5. mTOR Effect on Cornea.- Chapter 6. mTOR Effect on Anterior Segment.- Chapter 7. mTOR Effect on Lens.- Chapter 8. mTOR Effect on Retina.- Chapter 9. mTOR Effect on Retinal Pigment Epithelium.- Chapter 10. mTOR Effect on Optic Nerve.- Chapter 11. mTOR Effect on the Brain.- Chapter 12. mTOR Alterations.