Informationen zum Autor Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, and The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences at UCLA. He is past president of the American Clinical Neurophysiology Society, the American Epilepsy Society, and the International League against Epilepsy, and is past co-chair of the Global Campaign against Epilepsy. His bibliography lists over 1,000 publications and over 30 books, and he is principal investigator on three research grants from the National Institute of Neurological Disorders and Stroke. He has received numerous awards and honors, including a Fulbright Scholarship, a Guggenheim Fellowship, and a Javits Award. Klappentext According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Zusammenfassung This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Inhaltsverzeichnis PART I: INTRODUCTION; Chapter 1; TERMINOLOGY AND CLASSIFICATIONS; TERMINOLOGY; Epileptic Seizures; Definition; Discussion; Epilepsy Disorders; Definition; Discussion; Epileptic and Epilepsy; Definition; Discussion; Ictal, Postictal, and Interictal; Definitions; Discussion; Epileptogenesis and Epileptogenicity; Definition; Discussion; Epileptic Spike Focus, Epileptic Lesion, and Epileptogenic Zone or Region; Definition; Discussion; Control, Cure, and Drug Resistance; Definition; Discussion; Antiepileptogenesis, Prevention, and Disease Modification; Definition; Discussion; Nonepileptic Seizures; Definition; Discussion; CLASSIFICATIONS; Older Classifications of Epileptic Seizure; International Classification of Epileptic Seizures; Other Seizure Classifications; Older Classifications of the Epilepsies; The 1970 International Classification; The WHO Classifications; The 1985 and 1989 International Classifications; Recent Efforts to Revise the International Classifications; Practical Considerations; SUMMARY AND CONCLUSIONS; Chapter 2; PERSPECTIVES; EPILEPSY THEN-HISTORICAL PERSPECTIVE; Medical History; Ancient and Medieval Periods; The Modern Era; Epilepsy and Religion; Epilepsy and Genius; EPILEPSY NOW-EPIDEMIOLOGICAL PERSPECTIVE; Definitions of Incidence and Prevalence; Methodological Considerations; Estimations of Incidence and Prevalence; Global Burden of Disease; SUMMARY AND CONCLUSIONS; PART II: PATHOPHYSIOLOGY; Chapter 3; MECHANISMS OF NEURONAL EXCITATION AND SYNCHRONIZATION; THE NEURON; The Excitable Membrane and Its Microenvironment; Voltage gated Channels; Membrane Physiology; Intracellular Processes; Structure-Function Relationship of Neuronal Elements; Interneuronal Connections; ...

Autorentext
Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, and The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences at UCLA. He is past president of the American Clinical Neurophysiology Society, the American Epilepsy Society, and the International League against Epilepsy, and is past co-chair of the Global Campaign against Epilepsy. His bibliography lists over 1,000 publications and over 30 books, and he is principal investigator on three research grants from the National Institute of Neurological Disorders and Stroke. He has received numerous awards and honors, including a Fulbright Scholarship, a Guggenheim Fellowship, and a Javits Award.

Klappentext

According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology.

Zusammenfassung
This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr, this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology.

Inhalt

PART I: INTRODUCTION; Chapter 1; TERMINOLOGY AND CLASSIFICATIONS; TERMINOLOGY; Epileptic Seizures; Definition; Discussion; Epilepsy Disorders; Definition; Discussion; Epileptic and Epilepsy; Definition; Discussion; Ictal, Postictal, and Interictal; Definitions; Discussion; Epileptogenesis and Epileptogenicity; Definition; Discussion; Epileptic Spike Focus, Epileptic Lesion, and Epileptogenic Zone or Region; Definition; Discussion; Control, Cure, and Drug Resistance; Definition; Discussion; Antiepileptogenesis, Prevention, and Disease Modification; Definition; Discussion; Nonepileptic Seizures; Definition; Discussion; CLASSIFICATIONS; Older Classifications of Epileptic Seizure; International Classification of Epileptic Seizures; Other Seizure Classifications; Older Classifications of the Epilepsies; The 1970 International Classification; The WHO Classifications; The 1985 and 1989 International Classifications; Recent Efforts to Revise the International Classifications; Practical Considerations; SUMMARY AND CONCLUSIONS; Chapter 2; PERSPECTIVES; EPILEPSY THEN-HISTORICAL PERSPECTIVE; Medical History; Ancient and Medieval Periods; The Modern Era; Epilepsy and Religion; Epilepsy and Genius; EPILEPSY NOW-EPIDEMIOLOGICAL PERSPECTIVE; Definitions of Incidence and Prevalence; Methodological Considerations; Estimations of Incidence and Prevalence; Global Burden of Disease; SUMMARY AND CONCLUSIONS; PART II: PATHOPHYSIOLOGY; Chapter 3; MECHANISMS OF NEURONAL EXCITATION AND SYNCHRONIZATION; THE NEURON; The Excitable Membrane and Its Microenvironment; Voltage gated Channels; Membrane Physiology; Intracellular Processes; Structure-Function Relationship of Neuronal Elements; Interneuronal Connections; Chemical Synapses; Electrotonic Synapses; Nonsynaptic Communication; Glia…