Guyton and Hall Textbook of Medical Physiology

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Director John E. Hall works at the Mississippi Center for Obesity Research, Department of Physiology and Biophysics, Jackson, Mississippi.

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2026 Textbook and Academic Authors Association (TAA) McGuffey Longevity Award Winner
Selected for 2026 Doody's Core Titles as an Essential Purchase in Physiology

A favorite text of physiology students worldwide, Guyton and Hall Textbook of Medical Physiology delivers the complex knowledge you need to master in a distinctive, easy-to-digest format. The fifteenth Edition of this bestselling text is fully up to date and provides clear, comprehensive coverage of the content most relevant to clinical and pre-clinical students. The unique format ensures maximum learning and retention of complex concepts: a larger font size emphasizes core information, while supporting information is detailed in a smaller font and highlighted in pale blue-making it easy to quickly skim the essential text or pursue more in-depth study.

• Focuses on core material and how the body maintains homeostasis to remain healthy, emphasizing the important principles that will aid in later clinical decision making
• Contains new information on physiology and the gut microbiome and clinically important sex differences in physiology lab values
• Presents information in short chapters using a concise, readable voice that facilitates learning and retention
• Utilizes two font sizes: a larger font for fundamentals, and a smaller font that highlights relevant integrated sciences, clinical examples, pathophysiology, or detailed mechanisms that students can read as needed
• Contains more than 1,200 full-color drawings and diagrams-all carefully crafted to make physiology easier to understand
• Includes online access to heart sounds, animations, self-assessment questions, and more
• An eBook version is included with purchase. The eBook allows you to access all of the text and figures, with the ability to search, make notes and highlights, and have content read aloud

Inhalt

UNIT I: Introduction to Physiology: The Cell and General Physiology

1. Functional Organization of the Human Body and Control of the "Internal Environment"
   Cells Are the Living Units of the Body
   Extracellular Fluid-The "Internal Environment"
   Homeostasis-Maintenance of a Stable Internal Environment
   Control Systems of the Body
   Physiological Variability
2. The Cell and Its Functions
   Organization of the Cell
   Cell Structure
   Functional Systems of the Cell
   Locomotion of Cells
3. Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction
   Cell Nucleus Genes Control Protein Synthesis
   Transcription-Transfer of Cell Nucleus DNA Code to Cytoplasm RNA Code
   Translation-Formation of Proteins on the Ribosomes
   Protein Enzymes Control Synthesis of Other Substances in the Cell
   Regulation of Gene Function and Biochemical Activity in Cells
   The DNA-Genetic System Controls Cell Reproduction
   Cell Differentiation
   Apoptosis-Programmed Cell Death
   Cancer

UNIT II: Membrane Physiology, Nerve, and Muscle
4. Transport of Substances Through Cell Membranes
The Cell Membrane Is a Lipid Bilayer With Cell Membrane Transport Proteins
Diffusion
Active Transport of Substances Through Membranes
5. Membrane Potentials and Action Potentials
Basic Physics of Membrane Potentials
Resting Membrane Potential of Neurons
Neuron Action Potential
Propagation of the Action Potential
Importance of Energy Metabolism for Reestablishing Sodium and Potassium Ionic Gradients After Action Potentials Are Completed
Plateau in Some Action Potentials
Rhythmicity of Some Excitable Tissues-Repetitive Discharge
Special Characteristics of Signal Transmission in Nerve Trunks
Excitation-The Process of Eliciting the Action Potential
6. Contraction of Skeletal Muscle
Physiological Anatomy of Skeletal Muscle
General Mechanism of Muscle Contraction
Molecular Mechanisms of Muscle Contraction
Energetics of Muscle Contraction
Characteristics of Whole Muscle Contraction
7. Excitation of Skeletal Muscle: Neuromuscular Transmission and Excitation-Contraction Coupling
Neuromuscular Junction and Transmission of Impulses From Nerve Endings to Skeletal Muscle Fibers
Muscle Action Potential
Excitation-Contraction Coupling
8. Excitation and Contraction of Smooth Muscle
Contraction of Smooth Muscle
Regulation of Contraction By Calcium Ions
Nervous and Hormonal Control of Smooth Muscle Contraction

UNIT III: The Heart
9. Cardiac Muscle; The Heart as a Pump and Function of the Heart Valves
Cardiac Muscle Physiology
The Cardiac Cycle
Regulation of Heart Pumping
10. Rhythmical Excitation of the Heart
Specialized Excitatory and Conductive System of the Heart
Control of Excitation and Conduction in the Heart
11. Fundamentals of Electrocardiography
Waveforms of the Normal Electrocardiogram
Flow of Current Around the Heart During the Cardiac Cycle
Electrocardiographic Leads
12. Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis
Vectorial Analysis of Electrocardiograms
Vectorial Analysis of the Normal Electrocardiogram
Mean Electrical Axis of the Ventricular QRS and Its Significance
Conditions That Cause Abnormal Voltages of the QRS Complex
Prolonged and Bizarre Patterns of the QRS Complex
Current of Injury on the Electrocardiogram
Abnormalities in the T Wave
13. Cardiac Arrhythmias and Their Electrocardiographic Interpretation
Abnormal Sinus Rhythms
Heart Block Within the Intracardiac Conduction Pathways
Premature Contractions
Paroxysmal Tachycardia
Ventricular Fibrillation
Atrial Fibrillation
Atrial Flutter
Cardiac Arrest

UNIT IV: The Circulation
14. Overview of the Circulation: Pressure, Flow, and Resistance
Physical Characteristics of the Circulation
Basic Principles of Circulatory Function
Interrelationships of Pressure, Flow, and Resistance
15. Vascular Distensibility and Functions of the Arterial and Venous Systems
Vascular Distensibility
Arterial Pressure Pulsations
Veins and Their Functions
16. The Microcirculation and Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow
Structure of the Microcirculation and Capillary System
Vasomotion Causes Intermittent Capillary Blood Flow
Exchange of Substances Between the Blood and Interstitial Fluid
Interstitium and Interstitial Fluid
Fluid Filtration Across Capillaries
Lymphatic System
17. Local and Humoral Control of Tissue Blood Flow
Local Blood Flow Is Controlled in Response to Tissue Needs
Mechanisms of Local Blood Flow Control
Humoral Control of the Circulation
18. Nervous Regulation of the Circulation and Rapid Control of Arterial Pressure
Nervous Regulation of the Circulation
Special Features of Nervous Control of Arterial Pressure
19. Role of the Kidneys in Long-Term Control of Arterial Pressure and in Hypertension: The Integrated System for Arterial Pressure Regulation
Renal-Body Fluid System for Arterial Pressure Control
Role of the Renin-Angiotensin System in Arterial Pressure Control
Summary of Integrated Multifaceted Systems for Arterial Pressure Regulation
20. Cardiac Output, Venous Return, and Their Regulation
Normal Values for Cardiac Output at Rest and During Activity
Control of Cardiac Output By Venous Return-Frank-Starling Mechanism of the Heart
Methods for Measuring Cardiac Output
21. Muscle Blood Flow and Cardiac Output During Exercise; The Coronary Circulation and Ischemic Heart Disease
Blood Flow Regulation in Skeletal Muscle at Rest and During Exercise
Coronary Circulation
22. Heart Failure
Circulatory Dynamics in Heart Failure
Unilateral Left Heart Failure
Low-Output Cardiac Failure-Cardiogenic Shock
Edema in Patients With Heart…