Autorentext
David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree's catalyst in HIE in 1995. Volker Derdau is the Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist at Sanofi, based in Germany. With over 25 years of experience in the pharmaceutical industry, he is an expert in the area of homogeneous catalysis, including radiochemistry and photocatalysis. He is author of over 70 articles and patents.

Klappentext

Isotopically-Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications delves into the transformative developments in isotopic labelling, a crucial field underpinning advancements in chemistry, biology, and medicine. The book emphasizes innovative methodologies for synthesizing compounds labelled with isotopes such as tritium, carbon-14, and various stable isotopes. It also discusses the tools and technologies refined over recent years to enhance analytical precision in their study. By combining theory with practical applications, it serves as an invaluable resource for researchers and professionals seeking deeper insights into isotopic synthesis and utilization.

Additionally, the book explores emerging topics, including novel applications in drug development, environmental tracing, and biochemical research. It integrates findings that push the boundaries of isotopic analysis, offering perspectives on future trends and challenges in the field.

Inhalt

1. Introduction
   
   2. Recent advances in deuterium and tritium chemistry
   3. Carbon-14 and tritium radiolabeling of protein derivatives
   4. PET and SPECT isotopes: Basic radiochemistry, new trends, and applications in molecular imaging
   5. Recent developments for the synthesis of stable isotopically labeled compounds
   6. Preclinical and clinical studies of pharmaceuticals supported by labeled compounds
   7. Labeled compounds in agrochemical applications
   8. Emerging fields in the chemistry of isotopes and their applications
   9. Deuterated active pharmaceutical ingredients
   10. Green and sustainable approaches to isotope labeling