This volume is based on a meeting of the Fondation IPSEN, held in Paris on Sep tember 18, 1995 to address the main issues of nervous system stem cells biology. Cell replacement in the adult mammals is not unusual outside the nervous sys tem. In fact, the nervous system is unique in lacking the ability to replace cells, following damage. Most neurons, in the adult central nervous system are termin of the organism and are not replaced ally differentiated, exist through the life when they die. There are, however, regions of the postnatal brain that continue to produce new neurons, but the fate and longevity of those cells are not well known. Evidence exists that small populations of neurons continue to be born in the adult ventricular zone, olfactory epithelium and hippocampus. In the adult hippocampus, newly born neurons originate from putative stem cells that exist in the sub granular zone of the dentate gyrus. Progeny of these putative stem cells differentiate into neurons in the granular layer within a month of the cells' birth, and this late neurogenesis continues throughout the adult life of the rodent. By understanding the nature of progenitor cells present in the embryonic and adult brains, the change in their population dynamics during development, and the factors that influence their proliferation, fate choice and differentiation, it may be possible to develop a strategy to manipulate cells in situ to treat neuro degenerative diseases or the injured adult brain.

Klappentext

Understanding the developmental origin of the nervous system is important for two reasons. First, it is intellectually interesting as an example of the assembly of a multicellular system. Second, this knowledge will permit us to control the assembly and disassembly of this system in health and disease.This volume summarizes the state-of-the-art as to the CNS stem cells which give rise to the nervous system.

Inhalt
Stem Cells: The Lessons from Hematopoiesis.- NRSF: A Coordinate Repressor of Neuron-Specific Genes Expressed in CNS Neural Progenitor Cells.- Segregation of Cell Lineage in the Avian Neural Crest.- Comparative Strategies of Subependymal Neurogenesis in the Adult Forebrain.- Characterization of Neuronal Progenitor Cells of the Neonatal Forebrain.- Neurogenesis in the Adult Brain: Prospects for Brain Repair.- The Oligodendrocyte-Type-2 Astrocyte Lineage: In vitro and in vivo Studies on Development, Tissue Repair and Neoplasia.- Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous Systems.- Use of Conditionally Immortalized Neural Progenitors for Transplantation and Gene Transfer to the CNS.- The Origins of the Central Nervous System.- Transplantation and Differentiation of Neural Stem-Like Cells: Possible Insights into Development and Therapeutic Potential.