The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.

Includes supplementary material: sn.pub/extras

Inhalt

Cerebral hemorrhage animal models: Q. Ma, N. Khatibi, H. Chen, J. Tang, J. H. Zhang: History of Preclinical Models of Intracerebral Hemorrhage. - A. Manaenko, H. Chen, J. H. Zhang, J. Tang Comparison of different preclinical models of intracerebral hemorrhage. - H. Chen, J. H. Zhang: Cerebral amyloid angiopathy-related microhemorrhages in Alzheimer's disease: a review of investigative animal models. - B. Orakcioglu, M. Kentar, Y. Uozumi, E. Santos, P. Schiebel, A. Unterberg, O.W. Sakowitz: Multiparametric characterisation of the perihemorrhagic zone in a porcine model of lobar ICH. - J. Tang, J. Ai, R. Loch Macdonald: Developing a model of chronic subdural hematoma. - Y. Tada, Y. Kanematsu, M. Kanematsu, Y. Nuki, E. I Liang, K. Wada, H. Makino, T. Hashimoto: A mouse model of intracranial aneurysmtechnical considerations. - T. Lekic, R. P. Ostrowski, H. Suzuki, A. Manaenko, W. Rolland, N. Fathali, J. Tang, J. H. Zhang: The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats. - T. Tsubokawa, H. Joshita, Y. Shiokawa, H. Miyazaki: Hyperglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model. - Y. Xing, X. Jiang, Y. Yang, G. Xi: Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia. -T. Lekic, A. Manaenko, W. Rolland, J. Tang, J. H. Zhang: A novel preclinical model of germinal matrix hemorrhage using neonatal rats.

Pathophysiology of cerebral hemorrhage: J. Lok, W. Leung, S. Murphy, W. Butler, N. Noviski, E. H. Lo: Intracranial hemorrhage mechanisms of secondary brain injury. - R.F. Keep, G. Xi, Y. Hua, J. Xiang: Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?. - D.-Z. Liu, F. R Sharp: The dual role of src kinases in intracerebral hemorrhage. - H. Kim, H. Su, S. Weinsheimer, L. Pawlikowska, W. L. Young: Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. - N. Fathali, N. H. Khatibi, R. P. Ostrowski, J. H. Zhang: The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia. - F. Zhao, S. Song, W. Liu, R. F. Keep, G. Xi, Y. Hua: Red blood cell lysis and brain tissue-type transglutaminase upregulation in a hippocampal model of intracerebral hemorrhage. - X. Zhao, S. Song, G. Sun, J. Zhang, R. Strong, L. Zhang, J. C. Grotta, J. Aronowski: Cytoprotective role of haptoglobin in brain after experimental intracerebral hemorrhage. - Y. Gong, Y. He, Y. Gu, R. F. Keep, G. Xi, Y. Hua: Effects of aging on autophagy after experimental intracerebral hemorrhage
Z. Ye, Q. Xie, G. Xi, R. Keep, Y. Hua: Effects of gender on heart injury after intracerebral hemorrhage in rats
Y. Gu, Y. Hua, Y. He, L. Wang, H. Hu, R. F. Keep, G. Xi: Iron accumulation and DNA damage in a pig model of intracerebral hemorrhage
H. Suzuki, T. Sozen, Y. Hasegawa, W. Chen, K. Kanamaru, W. Taki, J. H. Zhang: Subarachnoid hemorrhage causes pulmonary endothelial cell apoptosis and neurogenic pulmonary edema in mice
Y. He, Y. Hua, R. F. Keep, W. Liu, M. M. Wang, G. Xi: Hemoglobin expression in neurons and glia after intracerebral hemorrhage

**Experimental treatment for cerebral hemorrhage
**P. R. Gigante, G. Appelboom, B. Y. Hwang, R. M. Haque, M. L. Yeh, A. Ducruet, C. P. Kellner, J. Gorski, S. E. Keesecker, E. Sander Connolly, Jr.: Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage
R. Ayer, V. Jadhav, T. Sugawara, J.H. Zhang: The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage
J. Tong, J. M. Latzman, J. Rauch, D. S. Zagzag, J. H. Huang, U. Samadani: Sonic hedgehog agonist fails to induce neural stem cell precursors in a porcine model of experimental intracranial hemorrhage
A. Manaenko, T. Lekic, J. H. Zhang, J. Tang: NC1900, An arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model
A. Manaenko, N. Fathali, S. Williams, T. Lekic, J. H. Zhang, J. Tang: Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage
L. Kueppers-Tiedt, A. Manaenko, D. Michalski, A. Guenther, C. Hobohm, A. Wagner, J. H. Zhang, D. Schneider: Combined systemic thrombolysis with Alteplase and early hyperbaric oxygen therapy in experimental embolic stroke in rats relationship to functional outcome and reduction of structural damage
L. H. Sansing, T. H. Harris, S. E. Kasner, C. A. Hunter, K. Kariko: Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage
A. Manaenko, T. Lekic, Q. Ma, R. P. Ostrowski, J. H. Zhang, J. Tang: Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage
T. Hatakeyama, M. Okauchi, Y. Hua, R. F. Keep, G. Xi: Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats
A. Manaenko, N. Fathali, N. H. Khatibi, T. Lekic, K. J. Shum, R. Martin, J. H. Zhang, J. Tang: Post-treatment with Sr49059 improve outcomes following an intracerebral hemorrhagic stroke in mice
H. Hu, L. Wang, M. Okauchi , R. Keep, G. Xi, Y. Hua: Deferoxamine affects heat shock protein expression in heart after intracerebral hemorrhage in aged rats
T. Lekic, A. Manaenko, W. Rolland, K. Virbel, R. Hartman, J. Tang, J. H. Zhang: Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats
N. H. Khatibi, L. K. Lee, Y. Zhou, W. Chen, W. Rolland, N. Fathali, R. Martin, R. Applegate, G. Stier, J. H. Zhang: Endothelin receptor-A (Eta) inhibition fails to improve neonatal hypoxic-ischemic brain injury in rats
W. B. Rolland II, A. Manaenko, T. Lekic, Y. Hasegawa, R. Ostrowski, J. Tang, J. H. Zhang: FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice
S. Song, H. Hu, Y. Hua, J. A. Wang, G. Xi: Thrombin preconditioning reduces iron-induced brain swelling and brain atrophy
N. H. Khatibi, V. Jadhav, S. Charles, J. Chiu, J. Buchholz, J. Tang, J. H. Zhang: Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats
H. Suzuki, Y. Hasegawa, R. Ayer, T. Sugawara, W. Chen, T. Sozen, K. Kanamaru, W. Taki, J. H. Zhang: Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats
T. Lekic, A. Manaenko, W. Rolland, N. Fathali, M. Peterson, J. Tang, J. H. Zhang: Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats
D. Westra, W. Chen, R. Tsuchiyama, A. Colohan, J. Zhang: Pretreatment with normobaric and hyperbaric oxygenation worsens cerebral edema and neurologic outcomes in a murine model of surgically induced brain injury
T. Lekic, A. Manaenko, W. Rolland, R. P. Ostrowski, K. Virbel, J. Tang, J. H. Zhang: Beneficial effect of hyperbaric oxygenation after neonatal germinal matrix hemorrhage
H. Hu, S. Yamashita, S. Song, Y. Hua, R. F. Keep, G. Xi: Thrombin preconditioning attenuates iron-induced neuronal death
N. H. Khatibi, V. Jadhav, M. Saidi, W. Chen, R. Martin, G. Stier, J. Tang, J. H. Zhang: Granulocyte-colony stimulating factor treatment provides neuroprotection…