These proceedings of Falk Symposium 110 on `Intestinal Mucosa and its Diseases - Pathophysiology and Clinics' held at Titisee/Black Forest, Germany, 16-17 October 1998, comprehensively review salient clinical as well as scientific aspects - pending or settled - of the main intestinal diseases. In particular, chapters deal with infectious and neuroendocrine diarrhoeas, coeliac sprue, allergic enteropathy, intestinal lymphomas, colorectal carcinomas, and chronic inflammatory bowel diseases, in terms of clinical presentation as well as underlying mechanisms. This book therefore aims to bridge the gaps between basic science and clinics for the eventual treatment of patients afflicted with these diseases.

Inhalt

List of Principal Authors. Preface. Section I: Epithelial Transport and Diarrhoea. 1. Mechanisms of Intestinal Absorption and Secretion: An abbreviated review and update; E.B. Chang, C. Bookstein. 2. Epithelial Transport Changes in Experimental Inflammation; M.C. Berin, et al. 3. Enteropathogens and the Epithelial Proinflammatory Program; M.F. Kagnoff, L. Eckmann. 4. Enteropathogens and Diarrhae: The Role of Nerves and Mast Cells in Toxin-Mediated Diarrheas; J.T. LaMont, C. Pothoulakis. 5. Diarrhea in Neuroendocrine Disorders; R.T. Jensen. 6. Antidiarrheal Therapy; G.J. Krejs. Section II: Transport Proteins and Intestinal Diseases. 7. Molecular Cloning and Functional Analysis of Epithelial Transporters: Renal Na+P1-cotransport as an Example; J. Biber, et al. 8. Short-Term Regulation of NHE3 by Growth Factors/Protein Kinases Involves Vesicle Trafficking in Epithelial Cells and Fibroblasts; M. Donowitz, et al. 9. Towards Identification of the Molecular Mechanisms Involved in Transcriptional Regulation of the Intestinal Na+/Glucose Cotransporter (SGLT1); I.S. Wood, et al. 10. Iron Sensing and Regulation of Iron Transport; A. Rolfs, M.A. Hediger. 11. Molecular Mechanisms of Intestinal Calcium Absorption; M.D. Sitrin. 12. Peptide transport in the Small Intestine; H. Daniel. Section III: Epithelial Development and Differentiation. 13. Regulation of the Epithelial-Mesenchymal Cross-talk in the Gut; M. Kedinger, et al. 14. Epithelial Differentiation and Adaptation of the Intestine: Molecular Regulation; D.C. Rubin, et al. 15. NO as a Modulator of Mucosal Barrier Function in the Intestine; P. Kubes. 16. Function of Caudal-Related Homeobox Genes in the Intestinal Epithelium; P.G. Traber. 17. The Role of COX-2 in Intestinal Cancer; C. Williams, et al. 18. Mucin Gene Expression in the Gut; Y.S. Kim, et al. Section IV: Mechanisms of Gastrointestinal Carcinogenesis. 19. New Pathoepigenetic Aspects in GI Neoplasia &endash; State of the Art; T.A. Brasitus. 20. DNA Mismatch Repair Genes and Colorectal Cancer; C.R. Boland, J.M. Carethers. 21. Metastatic Tumor Growth; M. Zöller. 22. Apoptosis, Differentiation and the Control of Colonic Cell Numbers; A.C. Williams, et al. Section V: Mucosal Structure and Function. 23. Pathobiology of Active Intestinal Inflammation; J.L. Madara, D. Merlin. 24. Sampling and Antigen Presentation Strategies in Mucosal Tissues; J.-P. Kraehenbuhl, et al. 25. Epithelial Injury and Restitution; A.U. Dignas, et al. 26. Multi-step Assembly of the Right Junction: Implications for Intestinal Barrier Regulation and Disease; L.L. Mitic, et al. Section VI: New Insights into Small Intestinal Diseases. 27. Immunobiology of Celiac Disease; M.F. Kagnoff. 28. Clinical Problems in Coeliac Disease (CD); W.F. Caspary. 29. Functional Role of Keratinocyte Growth Factor (KGF) and Transforming Growth Factor-alpha (TGFalpha) in Mediating T-Cell-induced Crypt Cell Hyperplasia in the Gut; *M. Bajaj-Elliott, et al. 30. T- and B-Cell Lymphomas of the Intestine; M. Zeitz. 31. Allergic Enteropathy; S.C. Bischoff, et al. 32. Mucosal Vaccines and Oral Tolerance; J. Holmgren, et al. Section VII: Intestinal Inflammation and Tumour Growth: Cell-Cell Interactions. 33. Healing Gastrointestinal Mycosal Injury: Two Sides; D.K. Podolsky. 34. Microvascular Endothelial Cells and Leukocyte Emigration; P. Brandtzaeg, et al. 35. Epithelial Communication with Endothelial Cells &endash; Implications for IBD? R. Stoll, et al. 36. Cell and Molecular Cross Talk in Models of Mucosal Regeneration; F.C. Campbell, et al. 37. Novel Insights into the Regulatory Role of MRP8 (S100A8) and MRP14 (S100A9) in the Transendothelial Migration of Human Monocytes; C. Kerkhoff, et al. 38. Mucosal Immune Lessons from Gene Targeting Experiments; T. Dassopoulos, et al. Section VIII: Pathogenetic Mechanisms in Inflammatory Bowel Disease. 39. Experimental Models of Inflammation and their Relation to Human Inflammatory Bowel Disease; W. Strober, IJ. Fuss. 40. Regulation of the Inflammatory Response by Suppressor Cytokines; T. Kucharzik, et al. 41. A Role for Mast Cells in Intestinal Inflammation; E. Saperas. 42. Cytokine-Targeting Therapeutic Strategies in Inflammatory Bowel Disease; S.J.H. van Deventer. 43. Current Concept of the Role of Intestinal Lymphocyte Trafficking in the Organ-specific, Inflammation-related Extraintestinal Manifestations of IBD; N. Lügering, et al. Index.