Integrative Biology of Women's Health

This book details advancements in basic science across three areas of women's health: skeletal-muscle function, metabolic function, and cardiovascular function. It also seeks to place the basic science work in context within current understanding of the human.

Defining and understanding cellular and molecular mechanisms that are relevant to women's health has become a critical area of scientific pursuit. Until recently, very little effort has been place on defining or understanding critical differences between women and men that may be critical to the overall health of the woman. In 1990, the National Institutes of Health recognized this gap in knowledge resulting in the creation of the Office of Research on Women's Health. One of the purposes of this office was to advance the understanding of health issues from the women's perspective from both a basic and clinical scientific perspective. From a scientific evolution of understanding, the existence of this office is new and thus there has not been enough time for new information to integrate itself in our current scientific thought process. This book will seek to capture and disseminate our current understanding of scientific advancements relevant to women's health and provide the information to a broad audience. The purpose of this work is to discuss recent advancements in basic science across three areas of concern for women's health. In addition, the book will provide translational chapters that attempt to place the basic science work in context within our current understanding of the human. Although it is well acknowledge that gender differences exist across organ function which translates into differences in whole body function, until recently little effort has been made to define basic mechanisms within various tissues within the woman. This work will focus on recent scientific findings that are relevant to women's health and to provide novel and relevant information to interested scientists and clinicians.

Integrates the work of young, upcoming investigators with that of established investigators to encourage innovative thoughts and ideas Focuses on three areas: skeletal-muscle function, metabolic function, and cardiovascular function Provide translational chapters that attempt to place the basic science work in context within our current understanding of the human Includes supplementary material: sn.pub/extras

Klappentext
The purpose of Integrative Biology of Women's Health is to discuss and identify perspective areas from basic science to clinical interventions that are critical to the future of women's health. As of now there are critical knowledge gaps that exist in our understanding of physiological and cellular function in women that make the prediction of responses to specific interventions daunting. From a scientific evolution of understanding, the existence of research focused on women's health is relatively new and thus there has not been enough time for new information to integrate itself into our current scientific thought process. This book seeks to capture and disseminate our current understanding of scientific advancements relevant to women's health and provide the information to a broad audience. The scientific community has made significant advancements in understanding the unique aspects of women's health in multiple different tissues. Within this book leading researchers in three key areas: skeletal-muscle-bone function, metabolic function, and cardiovascular function have contributed chapters to enlighten or encourage new avenues of thought that would benefit women. The reader will be exposed to a wide range of experimental approaches including physiological, biochemical, molecular techniques in an effort to provide a comprehensive discussion about the biology of women's health. Integrative Biology of Women's Health is of great value to anyone who has a interest in sex related differences or estrogen-driven biological responses as they relate to muscle or bone function, metabolic or cardiovascular function.

Inhalt

1. Influence of ovarian hormones on skeletal muscle contractility.- 2. Novel Findings in Bone biology: impact on bone health for women.- 3. Estrogen Effects on Skeletal Muscle.- 4. The contribution of ovarian hormones to the cellular regulation of lipid metabolism.- 5. The role of estrogens in the regulation of peripheral glucose dynamics.- 6. The Impact of Estrogen Receptor a Expression in the Pathogenesis of Metabolic Syndrome- 7. Metabolic Health in the Aging Female: Human Perspective.- 8. Transitions Across a Lifetime: Unique Cardiovascular Physiology of Women and Relationship to Cardiovascular Disease Risk.- 9. Estrogen, Cardiac Protection and Aging.- 10. Diet and Exercise Are Potent Modulators of Cardiovascular Disease in Women.