The literature on co-trimoxazole (TMP jSMX) is voluminous, but in the main it consists of research reports. The same can be said of various symposia that have appeared. This volume attempts to present the current status of this antibacterial combination in a series of topical reviews, each of which represents a comprehensive summary of a segment of the field. The editor acknowledges with appreciation the help provided by JACKIE, JENKS, LEE KUYPER, and particularly, RUTH Ross in the preparation of the Subject Index, and thanks Burroughs Wellcome Co. for providing access to library and word processing facilities. Research Triangle Park GEORGE H. HITCHINGS List of Authors Dr. J. F. ACAR, Hospital Saint-Joseph, 7, rue Pierre-Larousse, F-75674 Paris Cedex 14 Dr. N. ANAND, National Information Centre for Drugs and Pharmaceuticals, Central Drug Research Institute, Chattar Manzil, P. O. Box No. 173, Lucknow, 226001jIND Dr. D. W. BARRY, The Wellcome Research Laboratories, Burroughs Wellcome Co. , 3030 Cornwallis Road, Research Triangle Park, NC 27709jUSA Dr. R. E. BLACK, Center for Vaccine Development, University of Maryland, Division of Infectious Diseases, 29 S. Greene Street, Bressler Building, Room 404, Baltimore, MD 21201jUSA Dr. J. J. BURCHALL, Department of Microbiology, The Wellcome Research Laboratories, Burroughs Wellcome Co. , 3030 Cornwallis Road, Research Triangle Park, NC 27709jUSA Dr. S. R. M. BUSHBY, The Wellcome Research Laboratories, Burroughs Wellcome Co. , 3030 Cornwallis Road, Research Triangle Park, NC 27709jUSA Dr. M. L.

Klappentext

With contributions by numerous experts

Inhalt
Trimethoprim/Sulfamethoxazole: An Overview.- A. Introduction.- B. Mechanisms of Action.- C. Resistance.- D. Clinical Use of TMP/SMX.- E. Use of TMP or SMX as Single Agents.- F. Adverse Effects.- G. Summary.- References.- Pharmacology and Biochemistry.- 1 Functions of Tetrahydrofolate and the Role of Dihydrofolate Reductase in Cellular Metabolism.- 2 Sulfonamides: Structure-Activity Relationships and Mechanism of Action.- 3 Dihydrofolate Reductase.- 4 Antibacterial Activity.- 5 Selective Inhibitors of Bacterial Dihydrofolate Reductase: Structure-Activity Relationships.- 6 Kinetics of Antibacterial Effects.- 7 Disposition and Metabolism of Trimethoprim, Tetroxoprim, Sulfamethoxazole, and Sulfadiazine.- 8 Preclinical Toxicity Testing of Co-trimoxazole and Other Trimethoprim/ Sulfonamide Combinations.- Clinical Pharmacology.- 9 Adverse Effect of Co-trimoxazole.- 10 Clinical Pharmacokinetics of Co-trimoxazole.- 11 Resistance: Genetics and Medical Implications.- Clinical Studies.- 12 Trimethoprim Alone: Clinical Uses.- 13 Inhibitors of Dihydrofolate Reductase as Antiprotozoal Agents.- 14 Pediatric Uses of Sulfonamides, Trimethoprim, and the Combination.- 15 Use of Co-trimoxazole in Urinary Tract Infection.- 16 Treatment of Genital Infections with Trimethoprim, Sulfonamides, and Combinations.- 17 Treatment of Enteric Infections and Combinations.- 18 Prostatitis.- 19 Co-trimoxazole in Chest Infections Including its Long-Term Use in Chest Disease.- 20 Treatment of Miscellaneous and Unusual Infections with Trimethoprim and Trimethoprim/Sulfonamide Combinations.