In Vitro Toxicology Systems

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.

Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

Addresses toxicity testing, in vitro, in a variety of different human system simulations Features difficult areas of toxicology such as carcinogenicity and nanotoxicology Benefits students and experts in the field of chemical safety assessment as well as a wider scientific audience Includes supplementary material: sn.pub/extras

Inhalt

The Past, Present and Future of Chemical Risk Assessment.- In Vitro Systems for Hepatotoxicity Testing.- In Vitro Methods for Cardiotoxicity Testing.- Renal Cell Culture.- Cellular Models for In Vitro Lung Toxicology.- In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints.- Blood Brain Barrier In Vitro Models and Their Applications in Toxicology.- Ocular Toxicity.- In Vitro Models for Ototoxic Research.- Dermal Toxicity: Skin Sensitization.- Immunotoxicity.- Reproductive Toxicity.- Evaluating Endocrine Disruption In Vitro.- Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity.- Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening.- Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing.- High Content Imaging Approaches for In Vitro Toxicology.- Application of Omics Technologies to In Vitro Toxicology.- Stress Response Pathways.- Translational Biomarkers, In Vitro and In Vivo.- Nanotoxicology.- Consideration of Metabolism in In Vitro Cellular Systems.- In Vitro Approaches to Predictive Biokinetics.- Extrapolating In Vitro Results to Predict Human Toxicity.- Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use.