Impact of Sleep and Sleep Disturbances on Obesity and Cancer

Sleep has recently been recognized as a critical determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization. In addition to having an impact on obesity, sleep abnormalities, both quantitative and qualitative, have now been shown to have significant effects on obesity associated comorbidities, including metabolic syndrome, premalignant lesions and cancer. Sleep problems and fatigue also constitute a significant challenge for the ever expanding group of cancer survivors. Moreover, circadian misalignment, such as that experienced by "shift workers" has been shown to be associated with an increased incidence of several malignancies including, breast, colorectal and prostate cancer, consistent with the increasing recognition of the role of clock genes in the metabolic processes. Of increasing concern is the accelerating incidence of sleep disorders in childhood, their association with childhood obesity and associated abnormalities of circulating cytokines, adipokines and metabolic factors, many of which are implicated as etiologic mediators of the connection between obesity and cancer.

Extensive studies have now been initiated to investigate the mechanisms by which disturbances in sleep duration, sleep continuity and sleep related breathing affect circadian rhythm, central and peripheral tissue oxygenation and metabolism, quality and quantity of dietary intake and circulating inflammatory cytokines and regulatory hormones. This volume aims to present the latest research on sleep, sleep disturbance and its correlation to obesity and cancer.

Focuses on the relation of sleep disorders, both qualitative and quantitative, to obesity and cancer across the lifespan Discusses epidemiologic considerations, research on mechanisms of sleep and cancer, as well as potential approaches to interventions Constitutes a valuable addition at the cutting edge of studies on Energy Balance and Cancer Includes supplementary material: sn.pub/extras

Autorentext

Dr. Susan Redline is the Peter C. Farrell Professor of Sleep Medicine at Harvard Medical School, Senior Physician in the Division of Sleep Medicine at Brigham and Women's Hospital, and Physician in the Division of Pulmonary Medicine at Beth Israel Deaconess Medical Center. Dr. Redline has won several scientific awards for her research in sleep, including the American Thoracic Society's 2012 Recognition Award for Scientific Accomplishments, which recognizes her outstanding scientific contributions in epidemiological research designed to understand the prevention and treatment of sleep disorders.

Dr. Nathan A. Berger is the Hanna-Payne Professor of Experimental Medicine and Director of the Center for Science, Health and Society. He is Professor of Medicine, Biochemistry and Oncology at Case Western Reserve University, School of Medicine. Dr. Berger is a member of many professional societies including the American Society of Hematology, American Society of Biological Chemists, American Society of Clinical Oncology, American Association for Cancer Research, American Society of Clinical Investigation, and the American Association of Physicians. Dr. Berger serves on and chairs many national peer review panels and committees for the National Cancer Institute. He chaired the NCI Scientific Review Group Subcommittee D for Clinical Research Program Project Grant Applications and the NCI/National Center for Complimentary and Alternative Medicine Special Emphasis Review Panel.

Klappentext

This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression.

Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.

Inhalt
Preface.- Sleep Across the Lifespan.- Effects of Sleep Deficiency on Hormones, Cytokines, and Metabolism.- Sleep Disorders and Melatonin.- Biomedical Effects of Circadian Rhythm Disturbances.- Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer.- Association of Sleep Apnea and Cancer: From Animal Studies to Human Epidemiological Data.- Shift Work, Obesity, and Cancer.- Sleep Disorders and Cancer Risk.- Contribution of Sleep Disturbance to Cancer Fatigue.- Sleep Disturbances in Cancer Survivors.- Sleep-focused interventions: Investigating the effects of sleep restriction on energy balance.- Index.