This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.

Provides comprehensive information on the component cells of skin Includes detailed descriptions of the mechanisms of skin diseases Furnishes updated scientific information by leaders in the field worldwide Combines basic science and clinical medicine of the skin Includes supplementary material: sn.pub/extras

Autorentext
Kenji Kabashima MD, PhD. Department of Dermatology Kyoto University Graduate School of Medicine 54 Shogoin-Kawara, Sakyo, Kyoto 606-8507, Japan TEL +81-75-751-3310 FAX +81-75-761-3002 E-mail kaba@kuhp.kyoto-u.ac.jp

Inhalt

Preface.- 1 Overview: Immunology of the skin.- Part 1 Components of Skin Immune Cells.- 2 Stratum Corneum.- 3 Keratinocytes.- 4 Langerhans cells and dermal dendritic cells.- 5 T cells.- 6 gd T cells.- 7 B cells.- 8 Mast cells and basophils .- 9 Neutrophil .- 10 Macrophages.- 11 Myeloid derived suppressor cells.- 12 Lymphatic vessels.- 13 Hair follicles.- 14 Platelets.- 15 Adipose tissues.- Part 2 Immune Systems in the Skin.- 16 Innate immunity.- 17 C-type lectin receptors.- 18 Emergence of virulent Staphylococci overriding innate immunity of skin in community.- 19 Viral infection.- 20 Contact dermatitis.- 21 Atopic dermatitis: Common extrinsic and enigmatic intrinsic types.- 22 Psoriasis.- 23 Urticaria.- 24 Cutaneous adverse drug reactions: Stevens-Johnson syndrome and toxic epidermal necrolysis.- 25 Pemphigus .- 26 Anaphylaxis.- 27 Graft Versus Host Disease (GVHD).- 28 Rosacea in skin innate immunity.- 29 Cutaneous Lymphomas.- 30 Photodermatology- Therapeutic photomedicine for skindiseases.- 31 Collagen vascular disease.- Index.