Anti-native DNA antibodies and DNA are present in cryopreClpItates from patients with systemic lupus erythematosus and some other cryoglob ulinemic states. The data suggest that these antibodies may be bound in immune complexes. The demonstration of native DNA in these precipitates raises the likelihood that they represent specific antigen in these complexes. Whether or not these complexes play a pathogenetic role in nonlupus inflammatory diseases remains to be demonstrated. References Aarden, L. A., de Groot, E. R., and Feltkamp, T. E. W., 1975, Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immu nofluorescence technique, Ann. N.Y. A cad. Sci. 254:505. Agnello, V., Winchester, R. J. and Kunkel, H. G., 1970, Precipitin reactions of the Clq component of complement with aggregated 'Y-globulin and immune complexes in gel diffusion, Immunology 19:909. Anker, P., Stroun, M., and Maurice, P. A., 1975, Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system, Cancer Res. 35:2375. Bankhurst, A. D., and Williams, R. C., 1975, Identification of DNA-binding lymphocytes in patients with systemic lupus erythematosus,]. Clin. Invest. 56:1378. Bluestone, R., Goldberg, L. S., Cracchiolo, A., and Barrett, E. V., 1970, Detection and characterization of DNA in mixed (IgG-IgM) cryoglobulins, Int. Arch. Allergy Appl. Immunol. 39:16.

Inhalt
1 Functional Organization of the Glomerulus: Presence of Glycosaminoglycans (Proteoglycans) in the Glomerular Basement Membrane.- 2 Mechanisms of Glomerular Permselectivity.- 3 The Molecular Structure of Basement Membranes as It Relates to Function.- 4 Glomerular Basement Membrane Antigens.- 5 Physiologic Approaches to the Mechanisms of Glomerular Immune Injury.- 6 Physical Interactions between Macromolecules and the Glomerular Filter.- 7 Pathologic and Functional Correlations in the Glomerulopathies.- 8 Glomerular Mesangium: Introductory Remarks.- 9 The Influence of Hemodynamic Factors upon Mesangial Kinetics of Macromolecules.- 10 Deposition and Removal of Glomerular Immune Complexes: Relationships to the Mononuclear Phagocyte System.- 11 LCM Virus Infection and Nephritis.- 12 Diabetic Nephropathy: Relevance of Animal Models to the Understanding of Pathological Processes in Immune Renal Disease.- 13 Characterization of Rat Glomerular Cells in Vitro.- 14 Culture of Human Glomerular Cells.- 15 Immunochemical and Biochemical Studies of Human Glomerular Cells in Culture.- 16 Results of Immune Complex Detection in Glomerular Diseases.- 17 Nephritogenic Immune Responses Involving Basement Membrane and Other Antigens in or of the Glomerulus.- 18 Autoimmune Disease Induced in Rabbits by Administration of Mercuric Chloride: Evidence Suggesting a Role for Antigens of the Connective Tissue Matrix.- 19 Experimental Autoimmune Renal Tubulointerstitial Disease.- 20 Experimental and Human Anti-Tubular Basement Membrane Nephritis.- 21 Autoimmunity to Tamm-Horsfall Protein.- 22 Renal Antigens in Experimental Immune Complex Glomerulonephritis.- 23 Mechanisms of Proteinuria Induced by Antikidney Antibodies in Noninflammatory Experimental Glomerulonephropathy.- 24 The Pathogenesis of Autologous Immune Complex Glomerulonephritis in Rats.- 25 Immunopathogenesis of Murine SLE.- 26 Studies on Detection of Nephritogenic Immune Complexes.- 27 The Significance of Cryoimmunoglobulinemia in Immunologically Mediated Kidney Diseases.- 28 Relationship of Serum Cryoglobulins and Their Composition to Glomerulonephritis in Systemic Lupus Erythematosus.- 29 Cryoprecipitable Immunoglobulins with Native DNA Reactivity in the Glomerulopathies.- 30 The Role of Streptococcal and Glomerular Basement Membrane Antigens in Glomerulonephritis.- 31 The Contact (Hageman Factor) System in Inflammation.- 32 The Function of the Reticuloendothelial System in Autoimmune Disease.- 33 A Role of Mononuclear Phagocytes in Immunologically Induced Glomerulonephritis.- 34 Genetic Structure of the HLA Region and Implication for Function.- 35 Genetic Defects of the Complement Pathways: Relationship to HLA and Disease.- 36 Complement Abnormalities in Allergy and the Nephrotic Syndrome.- 37 Immunogenetic Aspects of Glomerulonephritis.- 38 Autoantibodies in Systemic Lupus Erythematosus.- 39 Serological Studies of Antibodies Reactive with RNA and RNA-Protein Antigens.- 40 Modulation of Autoimmunity by Sex Hormones.- 41 Thymic and T-Cell Function in Murine and Human Lupus.- 42 Immune Regulatory Abnormalities in Systemic Lupus Erythematosus.