This book introduces and reviews several topics for each human herpesvirus. One of the most important features of the book is that it covers aspects of both basic research and clinical medicine. Herpesviridae, a family of double-strand DNA viruses, has unique biological features by which these viruses establish latency after primary infection and reactivate in later life. Nine human herpesviruses are known so far, and each of them causes a variety of diseases in both primary infection and reactivation. Since the discovery of each human herpesvirus, an abundance of findings related to them has accumulated in basic research and clinical medicine. However, the vast majority of biological features is still masked in mystery. Furthermore, a strategy of treatment and prevention has not yet been established for most human herpesviruses. A wide range of readers will be interested in this volume with its treatment of problematic points and latest findings in the field.

Furnishes up-to-date knowledge from established experts Provides an overview and recent advances in this field Covers not only basic virology but also clinical issues

Autorentext

Yasushi Kawaguchi
Division of Molecular Virology, Department of Microbiology and Immunology
The Institute of Medical Science, The University of Tokyo
Tokyo, Japan

Yasuko Mori
Division of Clinical Virology
Kobe University Graduate School of Medicine
Kobe, Japan

Hiroshi Kimura
Department of Virology
Nagoya University Graduate School of Medicine
Nagoya, Japan

Inhalt

Preface.- Part I Alphaherpesviruses.- Chapter1The Role of Herpes Simplex Virus Glycoproteins in Mediating Cell Entry.- Chapter2 Virus assembly and egress of HSV.- Chapter3 Us3 protein kinase encoded by HSV: the precise function and mechanism on viral life cycle.- Chapter4 Oncolytic virotherapy by HSV.- Chapter5 Neurological disorders by human alphaherpesviruses.- Chapter6 Antiviral drugs against alphaherpesvirus.- Chapter7 Vaccine development for VZV.- Part II Betaherpesviruses.- Chapter8 Glycoproteins of HHV-6A and HHV-6B.- Chapter9 Betaherpesvirus virion assembly and egress.- Chapter10 Chromosomal Integration by Human Herpesviruses 6A and 6B.- Chapter11 Structural aspects of betaherpesvirus-encoded proteins.- Chapter12 Betaherpesvirus complications and management during stem cell transplantation.- Chapter13 Vaccine development for Cytomegalovirus.- Part III Gammaherpesviruses.- Chapter14 KSHV genome replication and maintenance in latency.- Chapter15 Signal transduction pathways associated with Kaposi's sarcoma-associated herpesvirus-related tumors.- Chapter16 Pathological features of Kaposi's sarcoma-associated herpesvirus infection.- Chapter17 EBV-encoded latent genes.- Chapter18 Encyclopedia of EBV-encoded lytic genes: an update.- Chapter19 Animal models of human gammaherpesvirus infections.- Chapter20 Gastritis-infection-cancer sequence of Epstein Barr virus-associated gastric cancer.- Chapter21 EBV in T/NK-cell tumorigenesis.- Chapter22 Vaccine development for Epstein-Barr Virus.