This book offers a basic understanding of the complex mechanisms that protect the brain from harmful substances while still allowing for essential functions such as nutrient transport and waste removal. It explores the blood-cerebrospinal fluid barrier (BCSFB) and the blood-brain barrier (BBB) in depth, focusing on the latest research, innovative techniques, and unique perspectives from researchers worldwide. The book also examines the clinical relevance of brain barrier dysfunction, with a particular focus on multiple sclerosis (MS) and the potential role of brain barriers in the development of MS, intricate relationship between brain barriers and infectious diseases and much more. With contributions from experts in neurobiology, microbiology, and biophysics, this book provides a multidisciplinary perspective.

Extensive research has been conducted on the cerebrovascular or cerebrospinal fluid barrier function. The recent development of a functional epithelial cell line derived from a human choroid plexus papilloma has paved the way for an in vitro model of the choroid plexus, which has been instrumental in elucidating the interplay between infection, metabolism, physiological functions, and disease. This book is an effort by the Editors to raise public knowledge of the cerebrovascular and cerebrospinal fluid barriers.

With broad coverage of topics in "Human Cerebrospinal Fluid and Cerebrovascular Barrier", it is ideal for researchers studying cerebrovascular or cerebrospinal fluid barrier interested in staying up to date on the latest developments. Healthcare providers and researchers working to develop new treatments for MS, infectious diseases of the central nervous system and other neurological disorders will also value this book. The book provides students of medicine, pharmacy, biology, and engineering with a comprehensive understanding of the structure and function of brain barriers. Those seeking a thorough introduction to the field will also find the book enjoyable.

Includes contributions from researchers around the world, providing unique perspectives on the research Examines the clinical relevance of brain barrier dysfunction, with a particular focus on multiple sclerosis (MS) Explores innovative techniques, including 3D modeling and stem cell in vitro models of the BBB

Autorentext

Associate Prof. Christian Schwerk:

Associate Prof. Dr. Christian Schwerk is a molecular and cellular biologist heading the infectious diseases research laboratory at the Department of Pediatrics, Pediatric Infectious Diseases, of the Medical Faculty Mannheim, Heidelberg University. He obtained his doctorate from the Institute of Cellular Biology (Cancer Research) at the University Hospital Essen, Germany and has worked in several international research institutions. Dr. Schwerk has published more than 70 peer reviewed publications and serves on the editorial boards of international journals.

Prof. Horst Schroten

Professor Dr. Horst Schroten is Director of the University Children's Hospital, Medical Faculty Mannheim, Heidelberg University. His scientific focus is on research into the pathogenesis of infectious diseases, in particular bacterial and viral meningitis. After holding a professorship for pediatric infectiology at the University of Düsseldorf, he was appointed to the Chair of General Paediatrics at the Mannheim Medical Faculty Heidelberg University on March 1, 2008. From 2001-2005 he was the President of the German Society for Pediatric Infectious Diseases and has published more than 200 peer-reviewed scientific publications.

Prof. Hiroshi Ishikawa

Professor Hiroshi Ishikawa graduated from The Jikei University School of Medicine in 1968, received Medical doctor Science 1972. In 1974, associate professor at Tohoku University School of Medicine. In 1985, appointed chairman of the Department of Histology and Embryology at The Jikei University School of Medicine. From 2003 to 2015 president of the Japanese Society of Human Cell. Since 2003 he has been on the Human Cell editorial board. He has deposited 84 cell lines in the Riken Cell Bank and has published over 490 papers. In 1984, he received the Research Encouragement Award from the Japan Endocrine Society, and since then he has received numerous academic awards. Currently, he has established a clinical regenerative medicine laboratory at the Department of Neurosurgery, University of Tsukuba. He conducts research on regenerative medicine based on embryology, especially on the treatment of cerebral infarction by transplanting differentiation-induced nervous system cells derived from human dental pulp.

Inhalt

Part 1 BBB & BCSFB introductions.- 1 The History of the Blood-CNS-barriers.- Part 2 BCSFB/HIBCPP.- 2 An overview of human choroid plexus structure and transport functions.- 3 Detailed protocol for establishing HIBCPP cell line derived from human choroid plexus papilloma: Special reference to the neuroprotective effects of transthyretin produced by HIBCPP cells.- 4 Bitter taste receptors as gatekeepers of brain barriers.- 5 Changes in the Blood Choroid Plexus Barrier in Response to Transient Receptor Potential, Vanilloid 4 Channel Activation.- 6 The blood-cerebrospinal fluid barrier and brain manganese accumulation.- 7 "Autoimmune interactions of antibacterial antibodies with brain proteins on choroid plexus cells: is there a role for neurodevelopmental disorders?".- 8 Multiple Sclerosis and the bloodcerebrospinal fluid barrier.- 9 Viral infections of the CNS is it all about breaching barriers?.- 10 The Choroid Plexus: A Barrier to the Brain and a Target for Central Nervous System-Invading Bacteria.- 11 Brain Infection in African Sleeping Sickness.- 12 The Blood-CSF Barrier in Oncological Research.- Part 3 BBB.- 13 In vitro models of the blood-brain barrier to study multiple sclerosis pathogenesis.- 14 Construction and Functional Evaluation of 2D and 3D Human Blood-Brain Barrier Models.