Many women have to spend one third of their lives in a postmenopausal state and they should have a good quality of life during this period. Althoug HRT is well accepted as the logical treatment of climacteric problems, the prevalence rate is very low in some countries. The reasons for not accepting HRT are manifold and complex. The objective of this book is to describe the essential advances in basic and clinical research that forms the basis of current HRT and to give an overview of the efficacy and safety of HRT.

Book has been written by leading gynecologists, endocrinologists and pharmacologists from Japan, Germany and USA It represents the new scientific knowledge on the hormone replacement therapy

Inhalt
1 General Aspects of Worldwide HRT Use.- 2 General Aspects of HRT in Japan.- 3 Recent Advances in Steroid Receptor Research: Focusing on Estrogen Receptors.- 4 Global Effects of Estrogens in the Adult Central Nervous System.- 5 HRT and Brain Function Clinical Aspects.- 6 Hormone Replacement Therapy and Lipids.- 7 HRT and the Vascular System Direct Action of Estrogen on Vascular Smooth Muscle Cells.- 8 The Place of Estriol Add-Back Therapy in Women Treated with GnRH Agonist, with Reference to Bone Protection.- 9 Hypoestrogenic Bone Loss and HRT: The Predictive Value of Biochemical Markers of Bone Turnover.- 10 HRT and Climacteric Symptoms: Characteristics in Japanese Women.- 11 The Mechanisms of Bone Loss due to Estrogen Deficiency: Possible Role of Increased B-Lymphopoiesis in Bone Resorption.- Previous Volumes Published in this Series.