Written by leading experts, this book offers a picture of how HIV impairs the brain, focusing on emerging areas including genetic strains of the virus, interactions between advanced age and HIV, and the impact of HIV on the brain during antiretroviral therapy.

Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.

Summarizes the current state of knowledge regarding HIV and the brain

Primarily focuses on advanced age and HIV, international studies of HIV and the brain, and reviews the impact of long-term treatment of HIV

Provides the most comprehensive review of key clinical and research issues in contemporary HIV

Inhalt
Chapter 1 Neurocognitive changes in HIV: Evolution of Treatment of HIV Infection. Erna Milunka Kojic, M.D. Charles Carpenter, M.D. Chapter 2 Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes and epidemiology of Hepatitis C infection among HIV positive individuals. Karen T. Tashima, M.D., Aadia Rana, M.D. Chapter 3 New Insights into HIV Neuropathogenesis. Tory P. Johnson, M.S., Avindra Nath, M.D. Chapter 4 Neuropathological findings associated with long term HAART treatment. Ian. C. Anthony, Ph.D., Jeanne E. Bell, M.D. Chapter 5 Biomarkers of HIV related Central Nervous System Disease. Bruce James Brew MBBS MD FRACP, Scott L. Letendre MD Chapter 6 Neuroimaging Among HIV Infected Patients: Current Knowledge and Future Directions David F. Tate, Ph.D., Jared Conley, B.S., Dominik Meier, Ph.D., Bradford Navia, M.D., Ph.D., Ronald Cohen, Ph.D., Charles R.G. Guttmann, M.D. Chapter 7 The assessment of HIV-associated neurocognitive disorders: New challenges in the HAART era Chronic neuro-AIDS, long-term cognitive assessment, and new risk factors Lucette A. Cysique, Ph.D., Bruce J. Brew MBBS MD FRACP Chapter 8 The changing face of HIV-associated cognitive and neuropsychiatric disturbance. Ron Cohen, Ph.D. Chapter 9 Youth with HIV/AIDS: Neurobehavioral Consequences Susannah Allison, Ph.D., Pamela L. Wolters, Ph.D., Pim Brouwers, Ph.D. Chapter 10 Co-occurrence of HIV, Hepatitis C, and Substance Use Disorders: Effects on Brain Functioning. Raul Gonzalez, Ph.D., Phillip J. Quartana, Ph.D., Eileen M. Martin, Ph.D. Chapter 11 The Functional Impact of HIV-associated Neuropsychological Decline Matthew J. Wright, Ph.D., Ellen Woo, Ph.D., Terry R. Barclay, Ph.D., & Charles H. Hinkin, Ph.D. Chapter 12 Adjunctive therapy for long-term support of cognitive impairment Joshua T. Dearborn, M.A., Susan E. Maloney, M. A., Nicole Hicklin, M.A. Elizabeth M. Lane, B.A., Robert Paul, Ph.D. Chapter 13 HIV-1 Genetic diversity and its biological significance. Michael M. Thomson, M.D., Ph.D. Chapter 14 Opportunistic infections in the brain in developing countries Marcus Tulius T Silva, M.D., M.Sc., Ph.D., Beatriz Grinsztejn, M.D., M.Sc., Ph.D. Chapter 15 Impact of clade diversity on neuropsychological outcomes Robert Paul, Ph.D., Ned Sacktor, M.D., Lucette Cysique, Ph.D., Bruce Brew, M.D., Victor Valcour, M.D. Chapter 16 The effects of aging on HIV disease Robert C. Kalayjian, M.D., Lena Al-Harthi, Ph.D. Chapter 17 Neuropsychology of Healthy Aging Molly E. Zimmerman, Ph.D., Adam M. Brickman, Ph.D. Chapter 18 Interactions between Advanced Age and HIV Cognitive Impairment Victor Valcour, M.D., Aaron McMurtray , M.D.