An extraordinary development of the knowledge, concepts and biomedical applications has occurred during the past two decades in the biological sciences, including the Reticuloendothelial Sys tem (RES). For example, it is now widely recognized that distinct classes of cells are involved in the recognition of "exogenous" invaders of the body such as microorganisms and other foreign an tigens, as well as of "endogenous" parasites represented by trans formed neoplastic cells and altered "self" antigens. Prominent among cell populations involved in such recognition of antigens and subsequent immune responses are those constituting the RES. In recent years, there has been much discussion and indeed contro versy as to what constitutes such a system and even whether the term "RES" is appropriate. Some investigators feel that the phago cytes are the most important cells of the RES as they playa major role in the defense mechanism of the host. Mononuclear phagocytes include tissue macrophages ~s well as circulating monocytes and their precursors. Although phagocytosis is a major functional ac tivity, it is only one of their several functions. The important role of phagocytes and other mononuclear cells in antibody forma tion, cell-mediated immunity, specific and non-specific resistance to microorganisms and tumor cells, as well as homeostatic adjust ments in general has become the focus of attention for many inves tigators.

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of Part B.- Section 1 Immunologic and Pathologic Aspects of the RES.- The Role of the T Cell in the Immune Response.- Immunological Tolerance: New Parameters for B-Cell Tolerance In vitro.- RES Blockade: Effects on Immunity and Tolerance.- Modulation of the Expression of a Secondary IgG Antihapten Response In vitro.- External Control of a Shift in Antibody Synthesis.- Effect of Antigen on Localization of Immunologically Specific B Cells.- Localization of Immunoglobulins in Germinal Centers of Human Tonsils.- ?2-Microglobulin of Lymphocytes.- Effect of Reserpine on Serum Hemolysin Response in Mice.- The Preparation of an Antiserum Against Human Monocytes.- Lymphocyte Subpopulations: Analysis of T-Cell Rosette Characters.- Section 2 The RES in Immunopathology and Autoimmunity.- Immunopathology of the Nervous System.- Altered Neutrophil Function Induced by Serum from Patients with Systemic Lupus Erythematosus.- Primary Immunodeficiency Diseases.- Malnutrition, the Thymolymphatic System and Immunocompetence.- Antigen and Immune Complex Induced Suppression of Delayed Hypersensitivity.- Plasma Cell Surface Antigen in Thermal Burns, Carcinogenesis and Primary Immunodeficiencies.- Spontaneous Autoimmune Thyroiditis in the BUF Rat.- Antibody-Dependent Cell-Mediated Cytotoxicity to Target Cells Infected with Herpes Simplex Virus.- Section 3 The RES in Transplantation Immunology.- Immunogenetic Aspects of Allotransplantation.- Alloantibodies in Relation to the Rejection of Skin Allografts in the Mouse.- Immunosuppression of Rosette-Forming Cells.- Biological and Pathological Characteristics in Mouse Lines with Large Differences in Leukocyte Counts.- Cell-Mediated Immunity in Long Term Transplant Patients.- Section 4 The RES in Tumor Immunology.- The Interactions of a LeukemiaVirus with Cells of the RES.- Neoplastic Invasion and Metastasis Within the Lymphoreticular System.- Adoptive Immunotherapy of Spontaneous Leukemia-Lymphoma in AKR Mice.- Surface Morphology of Leukemia Virus-Infected Lymphoid Cells.- Host Immunoreactivity to CSA, a Tissue-Specific Antigen of Normal and Neoplastic Human Intestine.- Tissue Polypeptide Antigen (TPA) in Human Cancer Defense Responses.- Age-Dependent Regression of M-MSV Tumors in CBA/H Mice: Requirement for a Macrophage-Adherent Cell Population.- Host Protection by Cell-Mediated and by Humoral Immunity in Malignancy.- In vitro Tumor Growth Inhibition by Syngeneic Lymphocytes and/or Macrophages.- Inhibition of Growth and Dissemination of Shay Myelogenous Leukemic Tumor in Rats by Glucan and Glucan Activated Macrophages.- Macrophage Participation in a Spontaneously Regressing Syngeneic Tumor.- Interaction of Macrophages with Tumor Cells.- Workshop.- RES Radiobiology and Environmental Factors.- Radiation Effects on Cells of the RES.- Physiologic Mechanisms in Radiation Resistance.- Immunologic Aspects of Malnutrition.- Post-Congress Workshop Summary.- Methods in Basic Laboratory Immunology.- List of Participants.