This open access book offers a comprehensive review of hepatocellular carcinoma (HCC) with a particular focus on the pathobiology and clinical aspects of the disease, including diagnosis and treatment. HCC is becoming one of the most common causes of cancer-related death worldwide. It is the fifth most common malignancy in men and the ninth in women, with an estimated 500,000 to 1 million new cases annually around the world. Independent of its cause, cirrhosis is considered a major clinical and histopathological risk factor for HCC development. Five percent of all cirrhotic patients develop HCC every year. Diagnostic tools for HCC include blood tests, high-quality imaging studies and liver biopsy. The treatment of HCC depends on the size and location of the HCC and includes surgical resection, liver transplantation, endovascular approaches, percutaneous ablation, and medical treatments. The book is organized into four parts overview, diagnosis, management strategies, and recommendations and aims to provide surgeons and clinicians with a valuable resource for complete and up-to-date research on the clinical aspects and management of HCC.

This is an open access book, which means that you have free and unlimited access Covers the management of hepatocellular carcinoma Reports an overview on pathology and imaging of hepatocellular carcinoma Refers to the hepatocellular carcinoma Guidelines

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Giuseppe Maria Ettorre is currently Chief of the Transplantation Department at the San Camillo-Forlanini Hospital and National Institute of Infectious Disease L. Spallanzani in Rome. He is an internationally renowned expert in liver surgery and transplantation, being considered one of the pioneers of laparoscopic liver surgery. He received his surgical training at Sapienza University of Rome and completed his clinical fellowships at the Service of General Surgery of Hôpital Lariboisière in Paris, directed by Prof. Hautefeuille and Valleur, and at the Service of Hepatobiliary Surgery and Liver Transplantation of Hôpital Beaujon in Paris, directed by Prof. Jacques Belghiti. From April 2001 to 2007 he was head of the Liver Disease and Transplantation team of the Surgical Unit of Prof. Eugenio Santoro at the oncological hospital IFO - Istituto Regina Elena in Rome. Since 2009 he has been Chief of the General Surgery and Transplantation Unit of San Camillo-Forlanini Hospital of Rome,where he oversees a comprehensive surgical program for the liver, pancreas and bile ducts, including surgeries for malignant and non-malignant conditions. In the last two decades he has performed more than 2,000 complex hepatobiliary and liver transplantation procedures. He also helped pioneer minimally invasive techniques in liver resection for the treatment of cancer. He is a member of numerous scientific societies and is author of more than 350 peer-reviewed articles of surgical interest as well as serving as principal or co-investigator in more than 20 studies.

Inhalt
PART I: OVERVIEW.- Chapter 1. Epidemiological Aspects of Hepatocellular Carcinoma.- Chapter 2. Molecular and Genetic Mechanisms of Hepatocellular Carcinoma.- Chapter 3. Role of the Immune System in Hepatocellular Carcinoma.- Chapter 4. Underlying Liver Disease.- PART II: DIAGNOSIS.- Chapter 5. Imaging of Hepatocellular Carcinoma.- Chapter 6. Pathology of Hepatocellular Carcinoma.- Chapter 7. Hepatological Evaluation and Biomarkers.- PART III: TREATMENT.- Chapter 8. Percutaneous and Laparoscopic-Assisted Ablation of Hepatocellular Carcinoma.- Chapter 9. Endovascular Treatments of Hepatocellular Carcinoma.- Chapter 10. Indications for Surgery in Cirrhotic Patients.- Chapter 11. Laparoscopic Approach for the Treatment of Hepatocellular Carcinoma.- Chapter 12. Robotic Approach for the Treatment of Hepatocellular Carcinoma.- Chapter 13. Ultrasound-Guided Liver Resection and Parenchymal-Sparing Surgery.- Chapter 14. Surgical Margins for Hepatocellular Carcinoma.- Chapter 15. Major Hepatectomies for Hepatocellular Carcinoma.- Chapter 16. R1-Vascular Surgery for Hepatocellular Carcinoma.- Chapter 17. Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS).- Chapter 18. Re-Do Surgery for Hepatocellular Carcinoma: Indications and Results.- Chapter 19. Liver Transplantation for Hepatocellular Carcinoma.- Chapter 20. Downstaging Strategies Prior to Liver Transplantation.- Chapter 21. Hepatocellular Carcinoma Medical Therapy.- PART IV: SPECIAL CONSIDERATIONS.- Chapter 22. Surveillance for Patients at Risk of Developing Hepatocellular Carcinoma.- Chapter 23. Hepatocellular Carcinoma Recurrence: How to Manage.- Chapter 24. Liver Biopsy: How and When.- Chapter 25. Anesthesiologic Management During Surgery for Hepatocellular Carcinoma.