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Hepatocellular Carcinoma

  • Fester Einband
  • 364 Seiten
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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis... Weiterlesen
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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields.

By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.


Yujin Hoshida
University of Texas Southwestern Medical Center
Dallas, TX

Part 1: Clinical demographics and management
1. Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care
Naoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida
2. Hepatocellular Carcinoma Surveillance and Staging
Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai
3. Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance
Yueran Zhuo, Qiushi Chen, Jagpreet Chhatwal

Part 2: Diagnosis and prognostication
4. Radiological diagnosis and characterization of HCC
Naik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli
5. Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target Discovery
Connor West, Alyson P. Black, Anand S. Mehta
6. Molecular subtypes and genomic signatures of hepatocellular carcinoma for prognostication and therapeutic decision making
Sung Hwan Lee, Sun Young Yim, Jae-Jun Shim, Ju-Seog Lee
7. Liquid Biopsy in Hepatocellular Carcinoma
Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting

Part 3: Treatment
8. Surgical Therapies in Hepatocellular Carcinoma
Caitlin A. Hester, Adam C. Yopp
9. Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are Going
Patrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin
10. Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy
Ryosuke Tateishi, Naoto Fujiwara
11. Molecular-targeted therapies in hepatocellular carcinoma
Amit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard Kim 
12. Immune therapies
Zachary J. Brown and Tim F. Greten
13. Prevention Strategies for Hepatocellular Carcinoma
Derek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. Fuchs
Part 4: Molecular pathogenesis and therapeutic discovery
14. Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma
Hsin Hung, Xin Wei Wang
15. Stromal and Immune Drivers of Hepatocarcinogenesis
Antonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger, Thomas F. Baumert
16. Experimental Models for Preclinical Research in Hepatocellular Carcinoma
Pedro Molina-Sánchez, Amaia Lujambio


Titel: Hepatocellular Carcinoma
Untertitel: Translational Precision Medicine Approaches
EAN: 9783030215392
ISBN: 978-3-030-21539-2
Format: Fester Einband
Herausgeber: Springer, Berlin
Genre: Medizin
Anzahl Seiten: 364
Gewicht: 842g
Größe: H22mm x B239mm x T164mm
Jahr: 2019
Auflage: 1st ed. 2019