This volume presents a review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The Handbook begins with a review of fundamental physics of loading single and multiple chemical bonds on the nanometer scale. It contains a discussion of thermodynamic and kinetic models of binding forces and dissipation effects in nanoscale molecular contacts, covers practical aspects of modern single-molecule level techniques, and concludes with applications of force spectroscopy to chemical and biological processes. Computer modeling of force spectroscopy experiments is also addressed.

Provides an authoritative guide to planning, understanding, and analyzing modern molecular force spectroscopy experiments Presents state-of-the-art research at the nanoscale and single-molecule levels with an emphasis on biophysics Addresses computer modeling of force spectroscopy experiments Includes supplementary material: sn.pub/extras

Inhalt

Surface force apparatus measurements of molecular forces in biological adhesion
( Deborah Leckband , Univ. of Illinois, Urbana-Champaign).- Force spectroscopy with optical and magnetic tweezers ( Richard Conroy , Harvard University).- Chemical Force Microscopy 1: Nanoscale probing of fundamental chemical interactions ( Aleksandr Noy , LLNL, Dmitry V. Vezenov , Harvard University, and Charles M. Lieber , Harvard University).- Chemical Force Microscopy 2: Interactions in complex molecular assemblies ( Dmitry V. Vezenov , Harvard University, Aleksandr Noy , LLNL, and Charles M. Lieber , Harvard University).- Dynamic force spectroscopy with the atomic force microscope ( Phil Williams , University of Nottingham).- Simulation in force spectroscopy ( David L. Patrick , Western Washington University).- Probe tip functionalization: applications to chemical force microscopy ( Craig D. Blanchard , Albert Loui , and Timothy V. Ratto , LLNL).- The dynamical response of proteins under force.- ( Kirstine L. Anderson , Sheena E. Radford , D. Alastair Smith , and David J. Brockwell , University of Leeds).- Counting and breaking single bonds: Dynamic force spectroscopy in tethered single molecule systems ( Todd A. Sulchek , Raymond W. Friddle , and Aleksandr Noy , LLNL).- Direct mapping of intermolecular interaction potentials ( Paul D. Ashby , MIT)