Our goal is to develop automated methods for the segmentation of thr- dimensional biomedical images. Here, we describe the segmentation of c- focal microscopy images of bee brains (20 individuals) by registration to one or several atlas images. Registration is performed by a highly parallel imp- mentation of an entropy-based nonrigid registration algorithm using B-spline transformations. We present and evaluate different methods to solve the cor- spondence problem in atlas based registration. An image can be segmented by registering it to an individual atlas, an average atlas, or multiple atlases. When registering to multiple atlases, combining the individual segmentations into a ?nalsegmentationcanbeachievedbyatlasselection,ormulticlassi?erdecision fusion. Wedescribeallthesemethodsandevaluatethesegmentationaccuracies that they achieve by performing experiments with electronic phantoms as well as by comparing their outputs to a manual gold standard. The present work is focused on the mathematical and computational t- ory behind a technique for deformable image registration termed Hyperelastic Warping, and demonstration of the technique via applications in image regist- tion and strain measurement. The approach combines well-established prin- ples of nonlinear continuum mechanics with forces derived directly from thr- dimensional image data to achieve registration. The general approach does not require the de?nition of landmarks, ?ducials, or surfaces, although it can - commodate these if available. Representative problems demonstrate the robust and ?exible nature of the approach. Three-dimensional registration methods are introduced for registering MRI volumes of the pelvis and prostate. The chapter ?rst reviews the applications, xi xii Preface challenges,and previous methods of image registration in the prostate.

First time a work is being written which covers the role of image segmentation and image registration together Three-volume sets constitutes a real system for effective use in biomedical applications therapy, whether theory (the student) or application (the professional) Volumes II & III: Dedicated to registration algorithms using the combination of biomedical imaging modalities such as MR, CT, X-ray, PET, SPECT and fMRI Have diagnostic systems using jointly the segmentation and registration algorithms Includes CD-ROM with figures and Q&A test questions and solution sets per volume Includes supplementary material: sn.pub/extras

Autorentext
Jasjit Suri , Ph.D. has spent the last 20 years in the field of computer and electrical engineering, and more than a decade in imaging sciences. Dr. Suri has a masters in computer sciences from the University of Illinois, a doctorate from the University of Washington, Seattle, and will soon receive his EMBA from the Weatherhead School of Management at Case Western Reserve University, Cleveland, Ohio. Dr. Suri has published over 100 technical publications in medical imaging, is a senior member of IEEE, member of the engineering honor societies Eta-Kappa-Nu and Tau-Beta-Phi, and a recipient of the President's Gold Medal in 1980. Prof. Swamy Laxminarayan , D.Sci. championed the field of Biomedical Engineering for over 30 years having held a variety of senior positions within the industry. He is an internationally recognized scientist, engineer, and educator with over 200 technical publications in biomedical information technology, computation biology, signal and image processing, biotechnology, and physiological system modeling. Prof. Laxminarayan is a fellow of AIMBE and a recipient of IEEE 3rd Millennium Medal.

Klappentext

Handbook of Biomedical Image Analysis: Registration Models (Volume III) is dedicated to the algorithms for registration of medical images and volumes. This volume is aimed at researchers and educators in imaging sciences, radiological imaging, clinical and diagnostic imaging, biomedical engineering, physicists covering different medical imaging modalities and researchers in applied mathematics, algorithmic development, computer vision, signal processing, computer graphics and multimedia in general, both in academia and industry.

Key Features:

-- Medical image registration: theory, algorithms and case studies in surgical simulation, chest cancer, and multiple sclerosis

-- Level sets for segmentation and registration for medical volumes

-- Registration and non-rigid registration for pelvis and prostrate

-- Cross-entropy, reversed cross-entropy, and symmetric divergence similarity measures for 3D image registration: a comparative study

-- Stereo and temporal eye registration by mutual information maximization

-- Quantification of brain aneurysm dimensions from CTA for surgical planning of coiling interventions

-- Inverse consistent image registration

-- A computer-aided design system for segmentation of volumetric images

-- Inter-subject non-rigid registration: an overview with classification and the Romeo algorithm

-- Elastic registration for biomedical applications

-- Quo vadis, atlas-based segmentation

-- Elastic registration for biomedical applications

-- Future of image and volume registration techniques

About the Editors:

Jasjit Suri, Ph.D. has spent over 20 years in the field of computer and electrical engineering, and more than a decade in imaging sciences. Dr. Suri has a masters degree in computer sciences from the University of Illinois and a doctorate in Electrical Engineering from the University of Washington, Seattle.Dr. Suri has published over 125 technical publications in medical imaging, as well as being a senior member of IEEE and a member of the engineering honor societies Eta-Kappa-Nu and Tau-Beta-Phi, and a recipient of the President's Gold Medal in 1980. He is also a fellow of American Institute of Medical and Biological Engineering.

David Wilson, Ph D. is a Professor of Biomedical Engineering and Radiology at Case Western Reserve University, having gained his doctorate from Rice University. He has over 60 refereed journal publications and is co-owner of several patents. Professor Wilson has actively developed biomedical imaging at CWRU. He has led a faculty recruitment effort, and he has served as PI or has been an active leader on multiple research and equipment developmental awards given to CWRU, including an NIH planning grant award for an in vivo Cellular and Molecular Imaging Center and an Ohio Wright Center of Innovation award. Swamy Laxminarayan, Dsc championed the field of Biomedical Engineering for over 30 years, having held a variety of senior positions within the industry. He is an internationally recognized scientist, engineer, and educator and has been published in over 200 technical publications in biomedical information technology, computation biology, signal and image processing, biotechnology, and physiological system modeling. Prof. Laxminarayan is a fellow of AIMBE and a recipient of IEEE 3rd Millennium Medal.

Inhalt
Medical Image Registration: Theory, Algorithm, and Case Studies in Surgical Simulation, Chest Cancer, and Multiple Sclerosis.- State of the Art of Level Set Methods in Segmentation and Registration of Medical Imaging Modalities.- Three-Dimensional Rigid and Non-Rigid Image Registration for the Pelvis and Prostate.- Stereo and Temporal Retinal Image Registration by Mutual Information Maximization.- Quantification of Brain Aneurysm Dimensions from CTA for Surgical Planning of Coiling Interventions.- Inverse Consistent Image Registration.- A Computer-Aided Design System for Segmentation of Volumetric Images.- Inter-Subject Non-Rigid Registration: An Overview with Classification and the Romeo Algorithm.- Elastic Registration for Biomedical Applications.- Cross-Entropy, Reversed Cross-Entropy, and Symmetric Divergence Similarity Measures for 3D Image Registration: A Comparative Study.- Quo Vadis, Atlas-Based Segmentation?.- Deformable Image Registration with Hyperelasti…