This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians, clinicians, and commercial entities, including students of auditory and vestibular neuroscience, audiologists, otologists, and industry, all of whom may have interest in hair cell regeneration as a potential future therapy for hearing and balance dysfunction. In 2008, Springer published a SHAR volume on this subject (Hair Cell Regeneration, Repair, and Protection, Editors Richard Salvi and Richard Fay). Since that time, there has been considerable advancement in this field.This book provides a historical perspective on the field, but the emphasis is on more "prospective" views of the various facets of regeneration research, in the hope that the volume will stimulate new projects and approaches, focusing on the limitations of current knowledge and describing promising strategies for future work. The book will include thefollowing key features of hair cell regeneration:

• Cellular and molecular control hair cell regeneration in non-mammalian species (in particular zebrafish and chickens)

• Our current understanding of the capacity for hair cell replacement in mammals (rodents and humans).

• Signals controlling pro-regenerative behaviors in supporting cells, the hair cell progenitors.

• New techniques that have been applied to study the genetic and epigenetic regulation of hair cell regeneration in mammals and non-mammals.

• Contributions of stem cells toward building new tools to explore how hair cell regeneration is controlled and toward developing cells and tissue for therapeutic transplantation.

• Studies that have applied gene and drug therapy to promote regeneration in mammals.

Delivers a comprehensive understanding of the status of hair cell regeneration research Emphasizes prospective views of the various facets of regeneration research Includes coverage of tudies that have applied gene and drug therapy to promote regeneration in mammals

Autorentext
Dr. Mark Warchol is Professor of Otolaryngology at Washington University School of Medicine in St. Louis.

Dr. Jennifer Stone is Research Professor of Otolgaryngolldy/Head and Neck Surgery, University of Washington School of Medicine, Seattle.

Dr. Allison Coffin is an Associate Professor in the Department of Integrative Physiology and Neuroscience at Washington State University Vancouver.

Dr. Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park.

Dr. Richard R. Fay (Deceased) was Distinguished Research Professor of Psychology at Loyola University Chicago.

Inhalt

Sensory Regeneration in the Inner Ear: History, Strategies and Prospects.- Non-mammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery.- Cell Junctions and the Mechanics of Hair Cell Regeneration.- Mammalian Hair Cell Regeneration.- Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors.- Inner Ear Cells from Stem Cells a Path Towards Inner Ear Cell Regeneration.- Spiral ganglion neuron regeneration in the cochlea: regeneration of synapses, axons and cells.- Genetic and Epigenetic Strategies for Promoting Hair Cell Regeneration in the Mature Mammalian Inner Ear.