Autorentext
Dr. Hu is an Associate Professor in the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center. His work is focused on mRNA biology, with the ultimate goal of elucidating their functional aspects in drug addiction, and also to identify novel therapeutic strategies that could enhance neuronal function and survival in patients afflicted with these disorders. Dr. Xiong is a Professor in the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center and leader of the University of Nebraska Medical Center Neurophysiology Laboratory in the Center for Neurovirology and Neurodegenerative Disorders. He is a neuroelectrophysiologist working in the field of NeuroAIDS (the neurological complications of AIDS), which include neurocognitive impairment and HIV-associated dementia (HAD). Current research in his laboratory studies molecular and cellular mechanisms underlying HIV-1-associated cellular and synaptic dysfunction and injury, with the ultimate goal of identifying potential target(s) for the development of therapeutic strategies. Dr. Xiong is the author of Current Laboratory Methods in Neuroscience Research (Springer) and has additionally authored many book chapters.Dr. Buch is a Professor and Executive Vice-Chair of the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center. Her research focuses on understanding the neuropathogenesis of HIV/SIV infection using cell culture, rodents and macaques as model systems. She is the director of the Nebraska Center for Substance Abuse Research, the mission of which is to promote and enhance drug abuse research and mentor trainees in this area. Dr. Buch is a Member of the European Academy of Sciences, and a Member of the Royal Academy of Belgium.

Klappentext
HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the clinical manifestations, molecular and cellular mechanisms, and therapeutic strategies underlying HAND and its associated comorbidities. This book brings together cutting-edge research and clinical insights, making it an essential resource for researchers, clinicians, and students engaged in HIV-related studies and neurocognitive research. This resource also aims to advance our understanding of HAND to contribute to the development of novel diagnostic tools and therapeutic interventions for improved patient outcomes.

Inhalt

1. An overview of the mechanisms of HIV-1 infection, latency, pathogenesis, and eradication strategies from the CNS
   
   2. Central Nervous System Complications of Human Immunodeficiency Virus Infection
   3. Health LIteracy in HIV-associated Neurocognitive Disorders
   4. Neuroimaging insights into the CNS effects of HIV infection
   5. Early and upstream subcellular organellar events associated with HAND
   6. White matter loss and oligodendrocyte dysfunction in HAND
   7. Pathogenesis of HIV-associated pain
   8. Neuropathogenesis of HIV-associated neuropathic pain
   9. Neuropathic Pain in HIV and the role of the Autophagy pathway
   10. Host peripheral immune dynamics increase HIV-associated neurocognitive disorders incidence and progression
   11. The role of immunometabolism in HIV associated depression and cognitive impairment
   12. Role of extracellular viral regulatory proteins in neuropathogenesis
   13. Role of inflammasomes in HIV-1 and drug abuse-mediated neuroinflammation
   14. The Contribution of Myeloid Cells to HIV Neuropathogenesis
   15. Immunophilin ligands modulate phagocytosis and viral replication in HIV-infected macrophages
   16. Immunometabolic mechanisms of HIV-associated neurocognitive disorders and traumatic brain injury: Commonalities and contrasts between chronic and acute neurodegenerative pathologies
   17. Endolysosome dysfunction in HAND
   18. Evolving biomarkers for HIV-associated neurocognitive disorders (HAND)
   19. Intracellular immunity against HIV infection
   20. NeuroHIV and the Glymphatic System
   21. The p75 neurotrophin receptor: emerging role in the pathogenesis of mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive Disorders
   22. The Role of HIV-Associated Neuroendocrine Dysfunction in HAND
   23. Impact of SARS-CoV-2/COVID-19 on HIV-1-associated neurocognitive disorders
   24. Molecular mechanisms of dopaminergic transmission in NeuroHIV
   25. The effect of substance misuse on HIV persistence in the CNS: epidemiological, immunological, and molecular considerations
   26. Extracellular vesicles in alcohol- and tobacco-induced neuroAIDS
   27. NeuroHIV in the context of opioid use disorder: A complex and evolving relationship
   28. Impairment of cholesterol homeostasis induced by Nef-containing extracellular vesicles as a factor in HAND pathogenesis
   29. Long noncoding RNAs in immune response, viral infection, and opioid use
   30. Using cross-species behavioral tools to determine mechanisms contributing to HIV associated neurological disorders and comorbid substance use
   31. Therapeutic potential of Curcumin in treating HIV-1 associated neurocognitive disorders
   32. Targeting the Endocannabinoid System in HAND
   33. Predicting the effectiveness of combination treatment of Dolutegravir and Fluoxetine for Depressive disorders in HIV
   34. ANTIRETROVIRAL THERAPY AND ITS CEREBRAL VASCULAR TOXICITY
   35. Strategies for HIV-1 Elimination