Guanidino compounds comprise Creatine, Arginine, and the Guanidines. In the past two years there have been over 2000 published articles with the names of these compounds in the title. One can go to any nutrition or health food store and buy these as supplements because it is believed they improve health and athletic performance.

This volume includes an up to date summary of the scientific and clinical aspects of essentially all the biologically active Guanidino Compounds. The articles summarize the current scientific knowledge of these compounds with reference to relevant clinical conditions, and discuss the chemical, biological, and clinical functions of these compounds.

Inhalt
Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes.- Inhibition of arginine synthesis by urea: A mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.- Smooth muscle and NMR review: An overview of smooth muscle metabolism.- Methyl group deficiency and guanidino production in Uremia.- L-Canavanine as a radiosensitization agent for human pancreatic cancer cells.- The clinical syndrome of creatine transporter deficiency.- Creatine supplementation in health and disease: What is the evidence for long-term efficacy?.- A role for guanidino compounds in the brain.- Electron paramagnetic resonance imaging of nitric oxide organ distribution in lipopolysuccaride treated mice.- Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: Changing patterns in development and with increased activity.- Monocarboxylates and glucose utilization as energy substrates in rat brain slices under selective glial poisoning a 31P NMR study.- Creatine supplementation during college football training does not increase the incidence of cramping or injury.- Effects of creatine supplementation on performance and training adaptations.- Long-term creatine supplementation does not significantly affect clinical markers of health in athletes.- Creatine supplementation enhances anaerobic ATP synthesis during a single 10 sec maximal handgrip exercise.- Association of ecNOS gene polymorphisms with end stage renal diseases.- Importance of renal mitochondria in the reduction of TEMPOL, a nitroxide radical.- Effect of caffeine on metabolism of L-arginine in the brain.- Role of nitric oxide synthase activity in experimental ischemic acute renalfailure in rats.- Alteration of energy production by the heart in CRF patients undergoing peritoneal dialysis.- Oral L-arginine can reverse digital necrosis in Raynaud's phenomenon.- Creatine deficiency syndromes.- Human skeletal muscle creatine transporter mRNA and protein expression in healthy, young males and females.- Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans.- Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis.- Arginine deprivation and tumour cell death: Arginase and its inhibition.- Index to Volume 244.