This book presents the latest developments in glycoscience and outlines a roadmap for the next decade, reflecting Japan's leadership in this rapidly evolving field. Building on the previous edition, Glycoscience: Basic Science to Applications (2019), the Japan Consortium for Glycobiology and Glycotechnology (JCGG) has compiled this revised edition to foster global collaboration and accelerate innovation across the life sciences.

This edition contains 167 entries contributed by 170 experts and is organized into six thematic parts: emerging glycan technologies; medicine, healthcare, and diseases involving glycans; glycan-related pharmaceuticals; glycan-related foods and their functions; glycan-based functional materials; and glycoinformatics. Each entry offers a structured overview of the topic's current status, scientific and societal impact, industrial applicability, and future challenges.

The book is a distinctive and valuable resource for researchers, students, clinicians, industry professionals, and policymakers. It promotes interdisciplinary integration, supports education and outreach, and serves as a strategic guide for advancing glycoscience globally.

Extends Glycoscience beyond biomedicine to integrate food science, materials science, and advanced technologies Updates the 2019 roadmap predictions and outlines new directions for the next decade Introduces the Human Glycome Atlas, the first major initiative to map human glycan structures

Autorentext

Shoko Nishihara, Ph.D. Distinguished Professor and Director, Glycan and Life System Integration Center, Soka University President, Japan Consortium for Glycobiology and Glycotechnology (JCGG)

Dr. Nishihara received her Ph.D. in Chemistry from the University of Tokyo, specializing in protein structural analysis. She began her research career at the Jikei University School of Medicine, where she investigated the pathogenic mechanisms of Staphylococcus aureus. She subsequently pursued postdoctoral research in Drosophila development at the University of North Carolina and the Mitsubishi Kasei Institute of Life Sciences. After joining Soka University as a Lecturer (equivalent to Assistant Professor), she transitioned into glycobiology and established an interdisciplinary research program integrating developmental biology, glycoscience, and stem cell biology. Her current research focuses on glycan functions in stem cells and development, as well as the molecular basis of glycosylation-related disorders. Dr. Nishihara also serves on the Editorial Board of Glycoconjugate Journal.

Jun Hirabayashi, PhD. Designated Professor, Institute for Glyco-core Research, Nagoya University Vice-President, Japan Consortium for Glycobiology and Glycotechnology (JCGG)

Dr. Hirabayashi graduated from Tohoku University and began his academic career at Teikyo University, where he initiated foundational studies on animal lectins, now known as galectins. He later joined the National Institute of Advanced Industrial Science and Technology (AIST) in Tsukuba, focusing on the industrial application of glycoscience technologies such as frontal affinity chromatography and lectin microarrays. He is also a visiting professor at Kagawa University and a member of the Kagawa Rare Sugar Project. His research interests include biochemistry, glycoscience, glycotechnology, and lectin engineering.

Inhalt

Chapter 1.Introduction.- Chapter 2. Liquid Chromatography-Mass Spectrometry (LC-MS).- Chapter 3. Ion Mobility Mass Spectrometry (IM-MS).- Chapter 4. Current Status and Future of the Automated Glycan Analysis Technologies.- Chapter 5. Glycoproteomics.- Chapter 6. O-Glycomics of Glycoproteins.- Chapter 7. Glycolipidomics.- Chapter 8. Measurement of Sugar Metabolites.- Chapter 9. Single Cell Glycomics.- Chapter 10. Glycan Array.- Chapter 11. Lectin Blotting.- Chapter 12. Lectin Engineering.- Chapter 13. Antibodies Recognizing Glycans Created as Antigens from Human iPS Cells.- Chapter 14. EMARS Method.- Chapter 15. Structural Biology by H-D Exchange Method.- Chapter 16. Structural analysis of glycoproteins and related biological molecules by cryo-electron microscopy.- Chapter 17. Conformational Analysis of Glycans.- Chapter 18. Conformation Analysis of Glycans (2).- Chapter 19. Structural Analysis of Glycan-Related Proteins (1).- Chapter 20. Structural Analysis of Glycan-Related Proteins (2).- Chapter 21. Glycoside hydrolases.- Chapter 22. Protein Structure Prediction (AlphaFold).- Chapter 23. Membrane Simulation and Imaging (1).- Chapter 24. Simulation and Imaging of Membranes (2).- Chapter 25. Imaging Using Labeled Glycans (1).- Chapter 26. Imaging with Labeled Glycans (2).- Chapter 27. Glycoside hydrolases-resistant glycans: Biological activity and application to molecular imaging.- Chapter 28. Mass Spectrometry Imaging (MSI).- Chapter 29. Visualization of Golgi apparatus glycosyltransferase.- Chapter 30. Synthetic Glycans.- Chapter 31. Glycan Synthesis by Microflow.- Chapter 32. Automation of Glycan Synthesis.- Chapter 33. New synthesis method for the production of N-glycans: Glycoproteins (1).- Chapter 34. Novel synthesis method for the production of standard glycan compounds: Glycoproteins (2).- Chapter 35. Novel synthesis method for the production of standard glycan compounds: Glycolipids.- Chapter 36. Novel synthesis method for the production of standard glycosides: Sialic acid containing glycans.- Chapter 37. Novel synthesis method for the production of standard glycan compounds: Glycosylphosphatidylinositol (GPI). Chapter 38. Synthetic Glycosaminoglycan (GAG).- Chapter 39. Genetically Modified Mice: Glycolipids.- Chapter 40. Genetically Modified Mice: Glycoproteins.- Chapter 41. Genetically modified mice: Glycosaminoglycan (GAG).- Chapter 42. Genetic modification: Small fish.- Chapter 43. Genetic modification: Yeast.- Chapter 44. Drosophila melanogaster.- Chapter 45. Caenorhabditis elegans.- Chapter 46. Plants and glycans.- Chapter 47. Chemical Biology.- Chapter 48. Role of glycans in evolution, development, and stem cells.- Chapter 49. Glycosylation in stem cells.- Chapter 50. Epigenetic regulation of glyco-genes.- Chapter 51. Involvement of glycans in the acquisition of drug resistance in cancer.- Chapter 52. Extracellular vesicles.- Chapter 53. Carbohydrate metabolism.- Chapter 54. Glycation reaction (Maillard reaction) and medicine.- chapter 55. Schizophrenia (Polysialic acid).- Chapter 56. Schizophrenia (Core fucose and polysialic acid).- Chapter 57. Spinal cord injury and glycosaminoglycan.- Chapter 58. Alzheimer's disease (AD)(1).- Chapter 59. Alzheimer's disease (AD)(2).- chapter 60. Parkinson's disease.