7th Jenner Glycobiology and Medicine Symposium Sunday5 W Wednesday 8 September 2004 John S. Axford StGeorge s, University of London, UK The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this ?nal frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed tore?ecttheseadvances.Allthemajorclinicalareaswereinvolved,withcontributions from pivotal players in science and medicine. As with our previous meetings, junior scientists were involved as we recognise that at the end of the next decade they will be in the driving seat. This introduction serves as a taster to whet your appetite. From embryogenesis to pathogenesis, glycosylation plays a pivotal role. Complex and hybrid N-glyans and O-fucose glycans are critical in oocyte devel- ment and function. This area must surely be a fertile ground for glycosylation research.

Includes supplementary material: sn.pub/extras

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Glycosylation: Disease Targets and Therapy.- Long Alkylchain Iminosugars Block the HCV p7 Ion Channel.- The Bovine Viral Diarrhoea Virus: A Model for the Study of Antiviral Molecules Interfering with N-Glycosylation and Folding of Enveloppe Glycoprotein.- Antibody Recognition of a Carbohydrate Epitope: A Template for HIV Vaccine Design.- Interaction of Schistosome Glycans with the Host Immune System.- The Mannan-Binding Lectin (MBL) Pathway of Complement Activation: Biochemistry, Biology and Clinical Implications.- Killer Cell Lectin-Like Receptors and the Natural Killer Cell Gene Complex.- Glycosylation Influences the Ligand Binding Activities of Mannose Receptor.- Human Immunoglobulin Glycosylation and the Lectin Pathway of Complement Activation.- Gelatinase B Participates in Collagen II Degradation and Releases Glycosylated Remnant Epitopes in Rheumatoid Arthritis.- Hyaluronan in Immune Processes.- Glycosylation and the Function of the T Cell Co-Receptor CD8.- Immunogenicity of Calreticulin-Bound Murine Leukemia Virus Glycoprotein gp90.- Glycosylation and GPI Anchorage of the Prion Protein.- Glycosylation Defects and Muscular Dystrophy.- Roles of Complex and Hybrid N-Glycans and O-Fucose Glycans in Oocyte Development and Function.- Mucin Oligosaccharides and Pigeon Fanciers' Lung.- Differential Glycosylation of Gelatinase B from Neutrophils and Breast Cancer Cells.- Detection of Glycosylation Changes in Serum and Tissue Proteins in Cancer by Lectin Blotting.- Carbohydrates and Biology of Staphylococcal Infections.- New Developments in Treating Glycosphingolipid Storage Diseases.- Fucosylated Glycans in Innate and Adaptive Immmunity.- New Insights into Rheumatoid Arthritis Associated Glycosylation Changes.- Production of Complex Human Glycoproteins in Yeast.-Relationships Between the N-Glycan Structures and Biological Activities Of Recombinant Human Erythropoietins Produced Using Different Culture Conditions and Purification Procedures.- Glycosylation of Natural and Recombinant Antibody Molecules.