Glioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy.

Important topics concerning molecular mechanisms responsible for glioma physiology and pathology Unique occasion to get an inside signaling induced by extracellular nucleotides, growth factors and cytokines in glioma cells New data concerning gliomas invasion and progression Role of cytoplasmic transcription factors, as STAT and SMAD in glioma pathogenesis Comparison of the nature of calcium signals in glioma cells with that in astrocytes and microglia

Klappentext

Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy.

Inhalt

1.introduction to purinergic signaling in the brain. - 2. adenosine signaling in glioma cells. - 3. cross-talk in nucleotide signaling in glioma c6 cells. - 4. calcium signaling in glioma cells the role of nucleotide receptors. - 5. purinergic signaling in glioma progression. - 6. cytoskeleton and nucleotide signaling in glioma cells. - 7. signaling determinants of glioma cell invasion. - 8. receptor tyrosine kinases: principles and functions in glioma invasion. - 9. tgf beta signaling and its role in glioma pathogenesis. - 10. stat signaling in glioma cells. - 11. cannabinoid signaling in glioma cells.