This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

Includes cutting-edge techniques to explore gene therapy for neurological disorders Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt

Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System.- Lentiviral Vectors for Gene Delivery to the Nervous System.- Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF).- Gene Delivery and Gene Therapy for Alzheimer's Disease.- Gene Therapy for Huntington's Disease.- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury.- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors.- Targeted Gene Therapy for Ischemic Stroke.- Adeno-Associated Viral Gene Therapy for Retinal Disorders.- Gene Therapy for Epilepsies.- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement.- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice.- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?.- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models.