This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.

First Handbook of Experimental Pharmacology focused on gastrointestinal (GI) pharmacology, in which the pathophysiology and established pharmacology of common GI disorders such as gastroesophageal reflux disease, peptic ulcer disease, gastroparesis, diarrhea, constipation, and irritable bowel syndrome are discussed Provides a timely state-of-the-art overview of the GI tract in health and disease The latest treatment approaches are discussed within the framework of the most recent mechanistic research Includes supplementary material: sn.pub/extras

Inhalt
Physiology of the Gastrointestinal Tract.- Upper GI Disorders; Gastropareis (with limited reference of GERD and PUD).- Post Operative Ileus: Pathophysiology, current therapeutic approaches.- Constipation & Diarrhea: Pathophysiology, current therapeutic approaches.- Irritable Bowel Syndrome: Pathophysiology, current therapeutic approaches.- Inflammatory Bowel Disease: Pathophysiology, current therapeutic approaches.- Pediatric GI Tract: pharmacological management of children with functional abdominal pain disorders.- Sex-Related Differences in GI Disorders.- Abnormal barrier function in GI Disorders.- Role of stress, anxiety and depression in the Pathophysiology of GI Disorders.- The Neuroimmune Function of the Gut.- Gut Microbiome, Probiotics and prebiotics.- Critical Evaluation of animal models of gastrointestinal disorders.- Serotonergic Mechanisms regulating the GI tract: experimental evidence and therapeutic relevance.- Cannabinoids receptors in regulating the GI tract: experimental evidence and therapeutic relevance.- Insights into the role of opioid receptors in the GI tract: experimental evidence and therapeutic relevance.- Ghrelin and motilin as targets to treat GI Disorders.- Centrally targeted pharmacotherapy for treated chronic abdominal pain.