1 Introduction to G-Protein-Coupled Signal Transduction and Human Disease.- 2 Albright Hereditary Osteodystrophy, Pseudohypopara-thyroidism, and Gs Deficiency.- 3 Gas-Activating Mutations: A Cause of Acromegaly, Thyroid Adenomas, Fibrous Dysplasia, and the McCune-Albright Syndrome.- 4 Ulcerative Colitis in Mice Lacking G?i2.- 5 G Proteins Regulating Insulin Action and Obesity: Analysis by Conditional, Targeted Expression of Antisense RNA in vivo.- 6 G;12- and G?3- Subunits of Heterotrimeric G Proteins : A Novel Family of Oncogenes.- 7 Hypo- and Hyperthyroidism Caused by Mutations of the TSH Receptor.- 8 Disorders Caused by Mutations of the Lutropin/ Choriogonadotropin Receptor Gene.- 9 Inactivating and Activating Mutations of the FSH Receptor Gene.- 10 Nephrogenic Diabetes Insipidus and Vasopressin Receptor Mutations.- 11 Disorders with Increased or Decreased Responsiveness to Extracellular Ca2+ Owing to Mutations in the Ca2+0-Sensing Receptor.- 12 Constitutively Active PTH/PTHrP Receptors Cause Jansen's Metaphyseal Chondrodysplasia.- 13 Mutation of the Growth Hormone-Releasing Hormone Receptor in the little Mouse.- 14 Functional Variants of the MSH Receptor (MC1-R), Agouti, and Their Effects on Mammalian Pigmentation.- 15 ACTH Resistance Syndromes.- 16 Altering Adrenergic Signaling and Cardiac Function in Transgenic Mice.- 17 Dopamine Receptors in Human Disease: Lessons from Targeted Mouse Mutants.- 18 The ?3-Adrenergic Receptor and Susceptibility to Obesity, the Insulin Resistance Syndrome, and Noninsulin-Dependent Diabetes Mellitus.

Zusammenfassung
This collection summarizes in-depth the state of knowledge concerning how cells communicate via G-protein-coupled signal transduction and how defects in these proteins and their receptors can cause serious human disease involving many different organ systems.