Through the integration of bioinformatic, genetic, transcriptomic, proteomic, metabolomic, phenomic and other massive datasets, genomics is revealing exciting new insights into fungal cell biology. The central theme of this volume is the strong impact that genomics is having upon our understanding of fungal biology, across a wide range of species, including model yeasts (such as Saccharomyces cerevisiae and Schizosaccharomyces pombe ), filamentous fungi (such as Neurospora crassa and Aspergillus nidulans) and pathogenic fungi (such as Magnaporthe grisae, Candida albicans, Cryptococcus neoformans and Histoplasma capsulatum ). World-renowned scientists address the following topics in these fungi: systems biology and evolution, circadian rhythms, apoptosis and stress responses, secretion, and environmental signalling networks. Particular emphasis is placed on fungal pathogenicity. Various genomic technologies are discussed, including genome-wide sequence comparisons, transcript profiling, proteomics, metabolomics and bioinformatics.

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Fungal Systems Biology and Evolution 1 Metabolomics and Systems Biology in Saccharomyces cerevisiaeJ.I. Castrillo and S.G. Oliver 2 Genome Evolution in Hemiascomycete YeastsL.J. Montcalm and K.H. Wolfe 3 Investigating the Evolution of Fungal Virulence by Functional GenomicsS. Ahmad, D.M. Soanes, M.C. Barooah and N.J. Talbot Fungal Rhythms and Responses 4 Circadian Rhythms, Photobiology and Functional Genomics in NeurosporaJ.J. Loros and J.C. Dunlap 5 Genomics of Protein Secretion and Hyphal Growth in AspergillusD.B. Archer and G. Turner 6 The Genomics of Stress Response in Fission YeastB.T. Wilhelm and J. Bähler 7 Programmed Cell Death and Apoptosis in FungiM. Ramsdale 8 Genomic Analysis of Cellular Morphology in Candida albicansM. Whiteway and A. Nantel Fungal Pathogenicity 9 Postgenomic Approaches to Analyse Candida albicans PathogenicityC.A. Munro, C. Fradin, O. Bader and B. Hube 10 Integration of Metabolism with Virulence in Candida albicansA.J.P. Brown 11 Regulators of Candida glabrata PathogenicityK. Haynes 12 Using Genomics to Study the Life Cycle of Histoplasma capsulatumA. Sil 13 Cryptococcus neoformans PathogenicityR.T Nelson and J.K. Lodge Biosystematic Index Subject Index