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From Molecules to Medicines

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  • 268 Seiten
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Proceedings of the NATO Advanced Study Institute on Integrating Crystallography in the Fight Against TerrorismErice, Italy29 May -... Weiterlesen
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Beschreibung

Proceedings of the NATO Advanced Study Institute on Integrating Crystallography in the Fight Against Terrorism
Erice, Italy
29 May - 8 June 2008

This volume comprises papers presented at the 40th Erice Course From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism , May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute. Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon

Klappentext

This volume comprises papers presented at the 40th Erice Course "From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism", May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute. Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon



Inhalt
Preface. List of Contributors. Surface Proteins of Gram-Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates; E.N. Baker.- The Rapid Crystallization Strategy for Structure-Based Inhibitor Design; T. Bergfors.- Fragment-Based Drug Discovery in Academia: Experiences from a Tuberculosis Programme; T. Heikkila et al.- Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia; S.W. Cowan-Jacob et al.- Integrating Crystallography Into Early Metabolism Studies; G. Cruciani et al.- The Foundations of Protein-Ligand Interaction; G. Klebe.- Structure-Based Design of TRNA-Guanine Transglycosylase Inhibitors; G. Klebe.- Progress on New Hepatitis C Virus Targets: NS2 and NS5A; J. Marcotrigiano.- Protein Structure Modeling; N. Eswar, A. Sali.- Structural Biology and Molecular Modeling in the Design of Novel DPP-4 Inhibitors; G. Scapin.- Tools to Make 3D Structural Data More Comprehensible: Emovie & Proteopedia; E.Hodis et al.- Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection against Chemical Threat Agents; J.L.Sussman, Israel Silman.- Protein Function Prediction from Structure in Structural Genomics and Its Contribution to the Study of Health and Disease; J.D. Watson, J.M. Thornton.- Crystal Structures of the ß2-Adrenergic Receptor; W.I. Weis et al.- Can Structures lead to better Drugs? Lessons from Ribosome Research; A.Yonath.-

Produktinformationen

Titel: From Molecules to Medicines
Untertitel: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism
Editor:
EAN: 9789048123377
ISBN: 9048123372
Format: Fester Einband
Herausgeber: Springer Netherlands
Anzahl Seiten: 268
Gewicht: 571g
Größe: H241mm x B160mm x T20mm
Jahr: 2009
Auflage: 2009

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