Free Radicals and Inflammation

As in so many fields of scientific endeavour following the molecular biology revo lution, our knowledge of the role of radicals not only in pathological states, but in basic physiology has developed exponentially. Indeed, our evolving concepts have, like so many political parties, been forced into dramatic "V-turns" and contortions. Within our working lives, we have had to debate whether radicals made any con tribution to any pathology, whilst now it is difficult not to entertain the view that every physiological process is pivotally controlled by exquisitely sensitive radical reactions. Inflammation is, of course, an example of pathology evolving from physiology, and in this book we have called upon both scientists and clinicians who have research interests in the complex switching mechanisms that sustain these transi tions. The book as a whole explores, from a physiological standpoint, how deter ministic radical systems sensitive to their initial conditions can interdigitate, iterate and feed back to control diverse cellular processes that create the inflammatory response. Whilst systems such as these to a mathematician would provide the basis for a chaotic response, one is forced to marvel how, for all stages of an inflammatory reaction, this system appears exquisitely controlled, making therapeutic manipula tion both possible and, to some extent, predictable.

Inhalt
Reactive oxygen/nitrogen species and acute inflammation: A physiological process.- Free radicals and pathology: current concepts.- The NADPH oxidase of neutrophile and other cells.- Nitric oxide a novel antimicrobial agent.- Xanthine oxidoreductase.- Inflammatory mediators free radicals and gene transcription.- Reactive metabolites of oxygen and nitrogen adhesion molecule expression and chronic joint inflammation.- Role of thioredoxin in the redox regulation of gene expression in inflammatory diseases.- Reactive oxygen species and the regulation of metalloproteinase expression.- Nitric oxide and inflammatory joint diseases.- Nitric oxide and bone destruction.- Why does chronic inflammation persist? A radical autoimmune perspective.- Radicals granuloma formation and fibrosis.- Reactive oxygen species nitric oxide and apoptosis.- Evolving measurements of radical products how much do they tell us about inflammation?.- Do antioxidants have a role in the therapy of human inflammatory diseases?.