The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Includes fundamental introductory chapters for focal drug delivery Describes drug delivery to body sites/system Provides an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences Includes supplementary material: sn.pub/extras

Autorentext

ABRAHAM J. DOMB is Professor for Medicinal Chemistry and Biopolymers at the Faculty of Medicine of the Hebrew University in Jerusalem, Israel. He earned bachelor's degrees in chemistry, pharmacy and law studies and a Ph.D. in chemistry from Hebrew University. He did his postdoctoral training at MIT and Harvard University and was R&D manager at Nova Pharm in Baltimore between 1988 and 1992. His primary research interests are in biopolymers, controlled drug delivery, cancer therapy, nanoparticulate systems, and forensic sciences.

WAHID KHAN obtained his master's degree and Ph.D. in pharmaceutics at the National Institute of Pharmaceutical & Educational Research (NIPER) in Mohali, India. He worked with Prof. Abraham J. Domb in The Hebrew University of Jerusalem, Israel, for his post-doctoral research. Currently, he is working as Assistant Professor in the Department of Pharmaceutics at NIPER in Hyderabad, India. His experience includes areas ranging from drug delivery and drug targeting to nanomedicine and biodesign of implantable medical devices.

Klappentext
The concept of Focal Drug Delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on this subject. Thus, the aim of the proposed book Focal Controlled Drug Delivery is to bring together leading experts and researchers in this field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. This book contains two sections- first section includes fundamental introductory chapters for focal drug delivery whereas, second section includes chapters describing drug delivery to body sites/system. The book allows clinical, pharmaceutical and biological scientists to offer their own perspectives on the subject, making it of potential interest to a wider audience than just drug delivery scientists. ABRAHAM J. DOMB is Professor for Medicinal Chemistry and Biopolymers at the Faculty of Medicine of the Hebrew University, Jerusalem, Israel. He earned Bachelor's degrees in Chemistry, Pharmacy and Law studies and PhD degree in Chemistry from Hebrew University. He did his postdoctoral training at MIT and Harvard Univ. USA and was R&D manager at Nova Pharm. Co. Baltimore USA during 1988-1992. During 2007-2012 he headed the Division of Identification and Forensic Sciences of the Israel Police. His primary research interests are in biopolymers, controlled drug delivery, cancer therapy, nanoparticulate systems, and forensic sciences.WAHID KHAN obtained his Master's and PhD in Pharmaceutics at the National Institute of Pharmaceutical & Educational Research (NIPER) Mohali India and worked with Prof. Abraham J. Domb in The Hebrew University of Jerusalem, Israel for his post doctoral research. Currently, he is working as Assistant Professor in Department of Pharmaceutics, NIPER, Hyderabad, India. He is having experience of working in areas of drug delivery, drug targeting, nanomedicine and biodesign of implantable medical devices. Dr. Khan has also won various national and international awards and fellowships including- Israel government prestigious PBC fellowships for outstanding Post-doctoral Researcher, Valazzi-Pikovsky and Lady Davis fellowship award.

Inhalt

Biodegradable Polymers for Focal Delivery Systems.- Implantable Medical Devices.- Systemic Targeting Systems-EPR Effect, Ligand Targeting Systems.- Liposomal formulations for Focal and Targeted Drug Delivery in Cancer and Other Diseases.- Polymer Drug Conjugate in Focal Drug Delivery.- Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs.- Treatment of Brain Tumors.- Intranasal Delivery of Neuropeptide-Loaded Nanoparticles and Their Application to Nervous System Therapeutics.- Focal Drug Delivery in Inner Ear Therapy.- Nanotechnology Based Ophthalmic Drug Delivery System.- Site Specific Ocular Nucleic Acid Delivery.- Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin.- Local Drug Delivery to the Oral Cavity.- Focal Drug Delivery for Management of Oral Infections.- Segmental-Dependent Drug Absorption and Delivery: The Stomach.- Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract.- Nanotechnology Applications in Local Arterial Drug Delivery.- Drug Eluting Stents.- Drug-Eluting Vascular Grafts.- Delivery Systems for Lymphatic Targeting.- Spatio-temporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair.- Spatio-temporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair.- Polymer Based Drug Delivery Systems for Solid Tumor Treatment.- Topical Nanointerventions for Therapeutic and Cosmeceutical Applications.- Focal Drug Delivery to the Nail.- Drug Delivery to Wounds, Burns and Diabetes Related Ulcers.- Vaginal Drug Delivery.- Prolonged Duration Local Anesthesia.