Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.

The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.

The only book on fibrogenesis to cover the field comprehensively, including lung, liver, heart, kidney, vessels, aging, etc... An essential reference book for the clinicians and basic researchers, who are dealing with complex fibrotic diseases Includes supplementary material: sn.pub/extras

Klappentext

Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options. The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.

Inhalt
Tissue Scarring.- Pathological Significance of Renal Expression of Proinflammatory Molecules.- Oxidative Stress, Lipoproteins and Angiotensin II.- Involvement of NF-?B in Renal Inflammation and Sclerosis.- Low-Denisty Lipoprotein and Glomerulosclerosis.- Molecular Developments in the Treatment of Renal Fibrosis.- Myocardial Infarction and Cardiac Fibrogenesis.- Cardiac Fibrosis and Aging.- Matrix Remodeling and Atherosclerosis Effect of Age.- Molecular and Cellular Aspects of Liver Fibrosis.- Recent Therapeutic Developments in Hepatic Fibrosis.- Reversibility of Liver Fibrosis.- Can Manipulation of Apoptotic Cell Death Benefit Tissue Scarring?.- Pulmonary Fibrogenesis.- Silica-Induced Inflammatory Mediators and Pulmonary Fibrosis.