For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.

Klappentext

These volumes cover all relevant aspects of recent research in estrogens and antiestrogens from chemistry, physiology, pharmacology to clinical applications. Particular emphasis is devoted to new developments in the area of estrogen receptors including estrogen receptor ß and the mode of action of novel partial estrogen agonists/antagonists. Further topics address the importance of estrogens and anti- estrogens in fertility, aging, cancer, animal husbandry and environment. Part II extends the information from Part I addressing the broad variety of pharmacological activities, their kinetics and toxicology. Particular emphasis is placed on the potential of these compounds in an impressive number of clincial indications. The chapters have been written by internationally renowned experts in their fields. Due to their broad scope, these volumes will be indispensable reference books in any library.

Inhalt
5: Pharmacology of Estrogens and Antiestrogens.- In Vitro and In Vivo Models to Characterise Estrogens and Antiestrogens.- Estrogen Receptor ? in the Pharmacology of Estrogens and Antiestrogens.- Interrelationship of Estrogens with other Hormones or Endocrine Systems.- Mammary Gland.- Cardiovascular System.- Bone.- Central Nervous System.- Liver Inclusive Protein, Lipid and Carbohydrate Metabolism.- Pharmacology of Antiestrogens.- Oncology.- Hormonal Resistance in Breast Cancer.- Pharmacology of Inhibitors of Estrogen Biosynthesis.- Pharmacology of Inhibition of Estrogen-Metabolizing Enzymes.- Pharmacology of Different Administration Routes - Oral vs Transdermal.- 6: Kinetics and Toxicology of Estrogens and Antiestrogens.- Pharmacokinetics of Exogenous Natural and Synthetic Estrogens and Antiestrogens.- Toxicology of Estrogens and Antiestrogens.- Estrogens and Sexually Transmitted Diseases.- 7: Clinical Application and Potential of Estrogens and Antiestrogens.- Hormonal Contraception.- Hormone Replacement Inclnding Osteoporosis.- A. The Menopause.- References.- Gynaecological Disorders.- A. Introduction.- B. Primary Amenorrhoea.- C. Secondary Amenorrhoea.- D. Bleeding Problems.- E. Anti-estrogens.- References.- Oncology.- A. Breast Cance.- B. Ovarian Cancer.- C. Endometrial Cancer.- References.- Cardiology.- A. Introduction.- B. Epidemiological Association Between Oral Contraceptive Use and Thrombosis.- C. Oral Contraceptives and Hemostasis.- D. Oral Contraceptives and Thrombophilia.- E. Summary.- References.- Urogenital Ageing and Dermatology.- A. Urogenital Aging.- B. Dermatology.- References.- Geriatric Neurology and Psychiatry.- A. Introduction.- B. Estrogen and the Brain..- C. Estrogen, Mood, and Behavior.- D. Estrogen and Cognition.- E. Stroke.- F. Dementia.- G.Other Neuropsychiatric Disorders..- H. Conclusions.- References.- Estrogens and Antiestrogens in the Male.- A. Introduction.- B. Age-Related Changes of Estrogen Secretion.- C. Metabolism and Pharmacokinetics of the Estrogens in the Male.- D. Genitourinary System.- E. Mammary Gland.- F. Liver.- G. Bone.- H. Cardiovascular System.- I. Central Nervous System.- J. The Influence of Environmental Estrogens (Xenoestrogens) on the Fertility of Men.- K. Regimens for Estrogen and Antiestrogen Treatment in Men.- L. The Therapeutic Value of Antiestrogens and Aromatase Inhibitors in Men.- M. The Concept of Non-Feminizing Estrogens.- References.- 8: Comparative Endocrinology.- Comparative Aspects of Estrogen Biosynthesis and Metabolism and the Endocrinological Consequences in Different Animal Species.- Therapeutic Use of Estrogens in Veterinary Medicine.- 9: Estrogens, Antiestrogens, and the Environment.- Environmental Estrogens.