For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.

Klappentext

These volumes cover all relevant aspects of recent research in estrogens and antiestrogens from chemistry, physiology, pharmacology to clinical applications. Particular emphasis is devoted to new developments in the area of estrogen receptors including estrogen receptor ß and the mode of action of novel partial estrogen agonists/antagonists. Further topics address the importance of estrogen and anti- estrogens in fertility, aging, cancer, animal husbandry and environment. Part I discusses the complex chemistry of steroidal and non-steroidal estrogens and antiestrogens as well as the molecular mechanisms of estrogen action. Information is provided on the metabolism and the various physiological and pathophysiological responses of estrogens. The chapters have been written by experts in the field of endocrinology for researchers, lecturers, physicians and pharmacologists. Due to their broad scope these volumes will be indispensable reference books in any library.

Inhalt
History of Estrogen Research.- 1 History of Estrogen Research.- 1: Chemistry of Estrogens and Antiestrogens.- 2 Steroidal Estrogens.- 3 Non-steroidal Estrogens.- 4 Antiestrogens and Partial Agonists.- 5 Structure Activity Relationships.- 2: Molecular Biology of Estrogenic Action.- 6 Structure and Function of the Estrogen Receptor.- 7 Estrogen-Regulated Genes.- 8 Regulation of Constitutive and Inducible Nitric Oxide Synthase by Estrogen.- 9 Non-Genomic Effects of Estrogens.- 10 Molecular Mechanisms of Antiestrogen Action.- 3: Biosynthesis and Metabolism of Endogenous Estrogens.- 11 Estrogen Transforming Enzymes.- 12 Metabolism of Endogenous Estrogens.- 4: Physiology and Pathophysiology of Estrogens.- 13 Phylogeny of Estrogen Synthesis, Extragenital Distribution of Estrogen Receptors and Their Development Role.- 14 Female Reproductive Tract.- 15 Estrogen and Brain Function: Implications for Aging and Dementia.- 16 Cardiovascular System.- 17 Immune System.- 18 Male Reproductive function.- 19 The Effect of Estrogens and Antiestrogens on the Urogenital Tract.- 20 Effects of Estrogens on Various Endocrine Regulations.