--- Written by World Renowned Leaders of the Estrogen Receptor and Breast Cancer Field to Celebrate the 60 th Anniversary of the Discovery of Estrogen Receptor --- Provides Comprehensive and Most Up-to-Date Information on the History, Recent Advancement and Future Perspective on the Exciting Topics about ER and Breast Cancer

--- Covering Both Basic Sciences and Clinical Practices and Written in a Style Suitable for Readings by Both Advanced Academia and General Audiences.

Autorentext

Dr. Xiaoting Zhang received his B.S. in Biochemistry and Microbiology from Zhejiang University and M.S. in Genetics from Institute of Genetics, Fudan University, China. He then moved to the United States and received his Ph.D. in Molecular Biology from the University of Iowa, followed by a postdoctoral study at the Rockefeller University. Dr. Zhang's laboratory focuses on understanding the molecular mechanism of estrogen receptor-mediated gene regulation in breast cancer metastasis and therapeutic resistance, and the development of RNA nanotechnology based therapeutics for their treatment. Dr. Zhang has received many awards and grants from major federal, national and local breast cancer funding agencies including NIH/NCI, DoD, American Cancer Society and Komen for the Cure Foundation. He also serves as a regularly invited grant reviewer for all these organizations, as well as international grant organizations such as Hong Kong Research Grant Council, the Marsden Fund of RoyalSociety of New Zealand and American Association for Cancer Research. He is a founding council member and chair of the nomination committee of the International Society of RNA Nanotechnology and Nanomedicine, and a member of the American Association for Cancer Research, American Society for Biochemistry and Molecular Biology and The Endocrine Society.

Inhalt

1. Introduction: On the discovery of Estrogen Receptor.- 2. Physiological and Pathological Roles of Estrogen Receptor.- 3. Estrogen Receptor Cofactors.- 4. ER-Mediated Gene Transcription.- 5. ER Transcriptome .- 6. Estrogen Receptor Regulation of Non-Coding RNAs in Breast Cancer .- 7. First Targeted Therapy --- History of Tamoxifen.- 8. Selective Estrogen Receptor Modulators (SERMs).- 9. New Estrogen Receptor Drugs.- 10. Endocrine Therapy in Clinical Practice.- 11. Structural Insights into ER and Anti-Estrogen Therapies.- 12. Molecular Mechanisms of Endocrine Resistance.- 13. Estrogen Receptor Mutants in Breast Cancer.- 14. Estrogen Receptor Beta and Isoforms in Breast Cancer.- 15. Xenoestrogens, Phytoestrogens and Breast Cancer.- 16. Emerging Approaches to Overcome Endocrine Resistance.