Esterases, Lipases, and Phospholipases

The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The purpose of this NATO-ARW was to bring together experts (both clinical and scientific) in all three interrelated fields to review the current basic and clinical position and discuss future developments particularly with respect to future research aimed at determining the basic biochemical lesion involving hydrolytic enzymes involved in human disease and the use of these enzymes in diagnosis. As well as formal lectures from established researchers, the meeting also involved a number of lively round-table discussions on future developments and presentations from younger research workers, all of which are recorded in this Proceedings and which contribute to the success of the meeting.

Klappentext

The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The purpose of this NATO-ARW was to bring together experts (both clinical and scientific) in all three interrelated fields to review the current basic and clinical position and discuss future developments particularly with respect to future research aimed at determining the basic biochemical lesion involving hydrolytic enzymes involved in human disease and the use of these enzymes in diagnosis. As well as formal lectures from established researchers, the meeting also involved a number of lively round-table discussions on future developments and presentations from younger research workers, all of which are recorded in this Proceedings and which contribute to the success of the meeting.

Zusammenfassung
Proceedings of a NATO ARW held in Bordeaux, France, September 22-24, 1993

Inhalt
Overview Lipases and Esterases: Reassessment of their Classification in the Light of their Three Dimensional Structure.- Esterases.- Serum Cholinesterase: Genetics, Enzymology, Diagnostic Use and the Association with Clinical Disorders.- Serum Cholinesterase in Diabetes.- Lipid Feeding and Serum Esterases.- Liver Carboxylesterases: Topogenesis of Intracellular and Secreted Forms.- Catalytic Properties and Classification of Phosphoric Triester Hydrolases: EDTA-Insensitive and EDTA-Sensitive Paraoxonases in Sera of Non-Diseased and Diseased Population Groups.- The Human Serum Paraoxonase Polymorphism and Atherosclerosis.- Hydrolysis of Xenobiotic Fatty Acid Esters by Carboxylesterases of Human Skin.- Human Monocyte/Macrophage Serine Esterase-1: Expression in Haematopoiesis and Transcript Deficiency in Alveolar Macrophages Derived from Patients Affected by Pulmonary Fibrosis.- Interactions between Pesticides and Esterases in Humans.- The Role of Esterases in the Pathogenesis of Disease and their use as Diagnostic Tools.- Cross-Reaction of a Human Anti-Paraoxonase Monoclonal Antibody with a Rat High Density Lipoprotein Peptide.- Carboxyl Ester Lipase in Acinar Cell Carcinoma of Pancreas.- Biochemistry of Lipases and Related Lipolytic Enzymes.- Hepatic Triglyceride Lipase and Lipoprotein Lipase action in vitro and in vivo.- Lipoprotein Lipase and Lysosomal Acid Lipase: Two Key Enzymes of Lipid Metabolism.- Lipoprotein Lipase Activity in the Pathological Metabolism of Lipoproteins.- Gastric Lipase: Characteristics and Biological Function of Preduodenal Digestive Lipases.- Pancreatic Cholesteryl Esterase in Health and Disease.- Pancreatic Lipase, Colipase and Enterostatin A Lipolytic Triad.- LCAT: From Structure to Clinical Significance.- Development of a SpecificAssay for Pancreatic Lipase Activity for Diagnostic Purposes.- Post-heparin Lipolytic Activities in Chronic Renal Failure Patients in Relation to Plasma Triglycerides.- Rabbit Pancreatic Lipase: Purification and Some Novel Catalytic Properties.- Phospholipases A2.- Phospholipase A2 and Prostaglandin Formation in Rat Glomerular Mesangial Cells.- Phospholipase A2 and the Pathogenesis of Multisystem Organ Failure in Experimental and Clinical Endotoxin Shock.- Transcriptional Regulation of Secreted Phospholipase A2 in Human HepG2 Cells, Rat Astrocytes and Rabbit Articular Chondrocytes.- Phospholipase A2 in Intensive-Care Patients: The German Multicentre Trial.- Phospholipases.- Study of Some Mechanisms that May Contribute to the Presence of High Levels of Phospholipase A2 Activity in Plasma of Patients with Septicemia.- Phospholipase Action in the Generation of Modified LDL.- Detection of Phospholipases A2 in Serum in Acute Pancreatitis.- Methods for the Determination of the Activity of Phospholipases and Their Clinical Application.- Phospholipases as Clinical Tools: Measurement.- Contributors.