Informationen zum Autor Eric V. Anslyn and Dennis A. Dougherty Klappentext This modern textbook makes explicit the many connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry, and biochemistry. In the latter part of the twentieth century, the field of physical organic chemistry went through dramatic changes, with an increased emphasis on noncovalent interactions and their roles in molecular recognition, supramolecular chemistry, and biology; the development of new materials with novel structural features; and the use of computational methods. Contemporary chemists must be just as familiar with these newer fields as with the more established classical topics. Modern Physical Organic Chemistry is intended to bridge that gap. In addition to covering thoroughly the core areas of physical organic chemistry - structure and mechanism - the book will escort the practitioner of organic chemistry into a field that has been thoroughly updated. The foundations and applicabilities of modern computational methods are also developed. Inhaltsverzeichnis Introduction to Structure and Models of Bonding.- Strain and Stability.- The Thermodynamics of Solutions and Noncovalent Binding Forces.- Molecular Recognition and Supramolecular Chemistry.- Acid-Base Chemistry.- Stereochemistry.- Energy Surfaces and Kinetic Analyses.- Experiments Related to Thermodynamics and Kinetics.- Catalysis.- Organic Reaction Mechanisms Part 1: Reactions Involving Additions and/or Eliminations.- Organic Reaction Mechanisms Part II: Substitutions at Aliphatic Centers and Thermal Isomerizations/Rearrangements.- Organotransition Metal Reaction Mechanisms and Catalysis.- Organic Materials Chemistry.- Advanced Concepts in Electronic Structure Theory.- Thermal Pericyclic Reactions.- Photochemistry.- Electronic Organic Materials.

Autorentext

Eric V. Anslyn, Dennis A. Dougherty

Klappentext

This modern textbook makes explicit the many connections between physical organic chemistry and critical fields such as organometallic chemistry, materials chemistry, bioorganic chemistry, and biochemistry. In the latter part of the twentieth century, the field of physical organic chemistry went through dramatic changes, with an increased emphasis on noncovalent interactions and their roles in molecular recognition, supramolecular chemistry, and biology; the development of new materials with novel structural features; and the use of computational methods. Contemporary chemists must be just as familiar with these newer fields as with the more established classical topics. Modern Physical Organic Chemistry is intended to bridge that gap. In addition to covering thoroughly the core areas of physical organic chemistry - structure and mechanism - the book will escort the practitioner of organic chemistry into a field that has been thoroughly updated. The foundations and applicabilities of modern computational methods are also developed.

Zusammenfassung
In additionto covering thoroughly the core areas of physical organic chemistry structure and mechanism this book will escortthe practitioner of organic chemistry into a field that has been thoroughlyupdated.

Inhalt

Chapter 1: Introduction to Structure and Models of BondingIntent and Purpose.1.1 A Review of Basic Bonding Concepts.1.2 A More Modern Theory of Organic Bonding1.3 Orbital Mixing - Building Larger Molecules1.4 Bonding and Structure of Reactive Intermediates1.5 A Very Quick Look at Organometallic and Inorganic BondingChapter 2: Strain and StabilityIntent and Purpose2.1 Thermochemistry of Stable Molecules2.2 Thermochemistry of Reactive Intermediates2.3 Relationships between Structure and Energetics; Basic Conformational Analysis2.4 Electronic Effects2.5 Highly Strained Molecules2.6 Molecular MechanicsChapter 3: Solutions and Noncovalent Binding ForcesIntent and Purpose3.1 Solvent and Solution Properties3.2 Binding Forces3.3 Computational Modeling of SolvationChapter 4: Molecular Recognition and Supramolecular ChemistryIntent and Purpose4.1 Thermodynamic Analyses of Binding Phenomena4.2 Molecular Recognition4.3 Supramolecular ChemistryChapter 5: Acid-Base ChemistryIntent and Purpose5.1 Brønsted Acid and Base Chemistry5.2 Aqueous Solutions5.3 Nonaqueous Systems5.4 Predicting Acid Strength5.5 Acids-Bases of Bioorganic Interest5.6 Lewis Acids/Bases and Electrophiles/NucleophilesChapter 6: StereochemistryIntent and Purpose6.1 Stereogenicity and Stereoisomerism6.2 Symmetry and Stereochemistry6.3 Topicity Relationships6.4 Reaction Stereochemistry: Stereoselectivity and Stereospecificity6.5 Symmetry and Timescale6.6 Topological and Supramolecular Stereochemistry6.7 Stereochemical Issues in Polymer Chemistry6.8 Stereochemical Issues in Chemical BiologySummary and OutlookChapter 7: Energy Surfaces and Kinetic AnalysesIntent and Purpose:7.1 Energy Surfaces and Related Concepts7.2 Transition State Theory (TST), and Related Topics7.3 Postulates and Principles Related to Kinetic Analysis7.4 Kinetic Experiments7.5 Complex Reactions - Deciphering Mechanisms7.6 Methods for Following Kinetics7.7 Calculating Rate Constants7.8 Considering Multiple Reaction CoordinatesSummary and OutlookChapter 8: Experiments Related to Thermodynamics and KineticsIntent and Purpose8.1 Isotope Effects8.2 Substituent Effects8.3 Hammett Plots, The Most Common LFER. A General Method for Examining Changes in Charges During a Reaction8.4 Other Linear Free Energy Relationships8.5 Acid/Base Related Effects / Brønsted Relationships8.6 Why do Linear Free Energy Relationships Work?8.7 Summary of Linear Free Energy Relationships8.8 Miscellaneous Experiments for Studying MechanismsChapter 9: CatalysisIntent and Purpose9.1 General Principles of Catalysis9.2 Forms of Catalysis9.3 Brønsted Acid/Base Catalysis9.4 Enzymatic CatalysisChapter 10: Organic Reaction Mechanisms Part 1: Reactions Involving Additions and/or EliminationsIntent and Purpose10.1 Predicting Organic Reactivity10.2 Hydration of Carbonyl Structures10.3 Electrophilic Addition of Water to Alkenes and Alkynes: Hydration10.4 Electrophilic Addition of Hydrogen Halides to Alkenes and Alkynes10.5 Electrophilic Addition of Halogens to Alkenes10.6 Hydroboration10.7 Epoxidation10.8 Nucleophilic Additions to Carbonyl Compounds10.9 Nucleophilic Additions to Olefins10.10 Radical Additions to Unsaturated Systems10.11 Carbene Additions and Insertions10.12 Eliminations to Form Carbonyls or "Carbonyl-Like" Intermediates10.13 Elimination Reactions for Aliphatic Systems, Formation of Alkenes10.14 Eliminations from Radical Intermediates10.15 Addition of Nitrogen Nucleophiles To Carbonyl Structures, Followed by Elimination10.16 Addition of Carbon Nucleophiles, Followed by Elimination - The Wittig Reaction10.17 Acyl Transfers10.18 Electrophilic Aromatic Substitution10.19 Nucleophilic Aromatic Substitution10.20 Reactions Involving Benzyne10.21 The SRN1 Reaction on Aromatic Rings10.22 Radical Aromatic SubstitutionsChapter 11: Organic Reaction Mechanisms Part II: Substitutions at Aliphatic Centers and Thermal Isomerizations/RearrangementsIntent and Purpose11.1 Tautomerization11.2 a-Halogenation11.3 a-Alkylations11.4 The Aldol Reaction11.5 Nucleophilic Aliphatic Substitution Reactions11.6 Substitution - Radical - Nucleophilic11.7 Radical Aliphatic Substitutions11.8 Migrations to Electrophilic Carbon11.9 Migrations to Electrophilic Heteroatoms11.10 The Favorskii Rearrangement and Other Carbanion Rearrangements11.11 Rearrangements Involving Radicals11.12 Rearrangements and Isomerizations Involving BiradicalsChapter 12: Organotransition Metal Reaction Mechanisms and CatalysisIntent and Purpose:12.1 The Basics of Organometallic Complexes12.2 Common Organometallic Reactions12.3 Combining the Individual Reactions into Overall Transformations and CyclesChapter 13. Organic Polymer and Materials ChemistryIntent and Purpose13.1 Structural Issues …