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Gives new insights into the role of the innate immune system in infection by gram-negative bacteria Presents a description of endotoxins according to their biosynthesis, genetic constitution, structure, function and mode of interaction with host cells Brings together contributions from researchers in the forefront of endotoxin research Provides fundamental understanding of the mechanism behind whole-body inflammation or sepsis.

Inhalt
I Structure and Properties of Endotoxins.- Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria.- Purification and Characterization of Lipopolysaccharides.- Endotoxins: Relationship Between Structure, Function, and Activity.- The Diversity of the Core Oligosaccharide in Lipopolysaccharides.- Salmonella-Regulated Lipopolysaccharide Modifications.- The Variation of O Antigens in Gram-Negative Bacteria.- Regulators of TLR4 Signaling by Endotoxins.- Membrane Partitioning: Is Location Everything When It Comes to Endotoxin Recognition?.- Infection, Treatment and Immunity.- Endotoxin Detection from Limulus Amebocyte Lysate to Recombinant Factor C.- The Role of Endotoxin in Infection: Helicobacter pylori and Campylobacter jejuni.- The Role of Pseudomonas Lipopolysaccharide in Cystic Fibrosis Airway Infection.- Development of Small-Molecule Endotoxin Sequestering Agents.- Development of an Anti-Endotoxin Vaccine for Sepsis.- Synthetic and Natural TLR4 Agonists as Safe and Effective Vaccine Adjuvants.- Targeting Endotoxin in the Treatment of Sepsis.- Lipopolysaccharides in Rhizobium-Legume Symbioses.- Lipopolysaccharides and Plant Innate Immunity.