Carole Mendelson has assembled a panel of leading investigators to critically review the various classes of endocrine, paracrine, and neuroendocrine factors that play a role in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung development and the synthesis of surfactant glycerophospholipids and proteins. Also extensively treated are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for all those actively investigating hormone action in pulmonary biology and medicine today.

Includes supplementary material: sn.pub/extras

Inhalt
1 The Glucocorticoid Domain in the Lung and Mechanisms of Action.- 2 Fetal Responses to Glucocorticoids.- 3 Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression.- 4 Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung.- 5 Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung.- 6 The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis: A First Approximation of the Epigenetic Rules.- 7 Corticotropin-Releasing Hormone and the Lung.- 8 Sex Differences in Fetal Lung Development: Biology, Etiology, and Evolutionary Significance.- 9 Retinoids and Lung Development.- 10 Insulin and Lung Development.- 11 The Insulin-like Growth Factor System and Lung.- 12 Platelet-Derived Growth Factor and Lung Development.- 13 Transforming Growth Factor-? Receptor Signaling and Lung Development.- 14 Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis.- 15 Parathyroid Hormone-Related Protein.- 16 Role of Neuroendocrine Cells in Fetal and Postnatal Lung.