Leukemia continues to offer the scientist a unique opportunity to gain new knowledge about the malignant transformation. As a result, this multi-authored volume, devoted to advances which have occurred over the last seven years, provides the reader with an important new understanding of leukemia, but perhaps even more important, predicts analogous, new developments in the other malignant diagnoses. In this respect, this volume represents the cutting edge of cancer research. This text is unique in that it includes in a single volume the leading contributors to their respective fields covering what the editors feel are the major advances in our knowledge of the biology and therapy of leukemia over the last seven years.

Inhalt

1. All trans retinoic acid as a targeting drug for differentiation therapy in acute promyelocytic leukemia.- 2. Hairy cell leukemia: New understanding of biology and treatment.- 3. Uses of polymerase chain reaction in leukemia: Detection of minimal residual disease and identification of novel genetic mutations.- 4. The cell surface receptor encoded by the proto-oncogene KIT and its ligand.- 5. Human T-cell lymphoma/leukemia retroviruses and malignancy.- 6. Fludarabine phosphate in the treatment of chronic lymphocytic leukemia: Biology, clinical impact, and future directions.- 7. The role of immunotherapy in the treatment of acute myeloblastic leukemia: From allogeneic bone marrow transplantation to the application of interleukin 2.- 8. Detection of minimal residual disease in ALL.- 9. Cytokines and myeloid-specific genes: Patterns of expression and possible role in proliferation and differentiation of acute myelogenous leukemia cells.- 10. The immunological treatment of human marrow in vitro in transplant biology.- 11. Monoclonal antibodies in the treatment of myelogenous leukemias.- 12. Prognosis and therapy of myelodysplastic syndromes.- 13. Multidrug resistance in leukemia.- 14. The molecular pathogenesis of the Philadelphia-positive leukemias: Implications for diagnosis and therapy.