This volume is unique in bringing the exciting range of antidepressant treatment developments together with a focus on their neurobiological mechanisms and how these interact with the known pathophysiology of depression. Current evidence for treatment efficacy is reviewed together with a discussion of where in the management pathway of this common condition, these new approaches might take their place.

Brings together wide range of novel neurobiological approaches to the treatment of depression Focus on critical neurobiological mechanisms Written by acknowledged experts in their fields

Inhalt

SSRIs A pharmacological cul-de-sac.- Neurobiology of SSRI withdrawal.- Pramipexole in the treatment of depression.- Opioid mechanisms in the treatment of depression.- Neuropsychological effects of antidepressants-translational studies.- KETAMINE FOR MAJOR DEPRESSIVE DISORDER.- Psilocybin and other classic psychedelics in depression.- Gut-brain axis and antidepressant treatment.- Anti-inflammatory drugs in the treatment of depression.- Mechanisms of TMS in Depression.- Mechanism of action of ECT in depression.- Vagal nerve stimulation in the treatment of depression.