This groundbreaking, multi-disciplinary title focuses on detection, measurement and interpretation of cancer precursors (defined as any lesion up to but not including invasive cancer, e.g. polyps as a pre-invasive lesion leading to colon cancer) at the most important sites where solid tumors occur, including the esophagus, colon, liver, etc. Evidence-based policy recommendations round out this essential volume of interest to pathologists, epidemiologists, cancer researchers, oncologists, and public health professionals.

Includes supplementary material: sn.pub/extras

Klappentext

Cancer Precursors is a groundbreaking, multidisciplinary text containing a comprehensive overview of methodological issues associated with the study of pre-cancerous conditions, as well as reviews of the contributions of descriptive, analytical, and molecular epidemiological research to knowledge about cancer precursors at specific anatomical locations. The research focuses on the early natural history of cancers, by helping to define the etiology of precursor lesions, improving the means of detecting them either directly or via testing of surrogate biomarkers, and by elucidating the role of remote causes leading to the early onset of such lesions.

Inhalt
Site-Specific Precancerous Conditions.- Biological Basis of Carcinogenesis.- Mechanisms and Biological Markers of Carcinogenesis.- Morphology of Cancer Precursor Lesions.- Issues Related to Measurement and Interpretation of Cancer Precursors.- Collection, Processing, and Analysis of Preneoplastic Specimens.- Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints.- Assessing Epidemiological Relations and the Role of Measurement Errors.- Site-Specific Precancerous Conditions.- Upper Aerodigestive Tract.- Esophagus.- Stomach.- Colon and Rectum.- Anus.- Liver.- Pancreas.- Lung.- Skin.- Breast.- Cervix.- Endometrium.- Ovary.- Vulva and Vagina.- Prostate.- Bladder.- Control of Cancer Precursors.- Screening.- Chemoprevention.- Evidence-Based Policy Recommendations on Screening and Prevention.- Conclusion.- Prospects.