Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.

Includes supplementary material: sn.pub/extras

Zusammenfassung
Presents a survey of the research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by neuropsychological tests, various genetic markers, and biological assays.

Inhalt
1 Early Diagnosis of Alzheimer's Disease: An Introduction.- 2 Current Approaches to the Clinical Diagnosis of Alzheimer's Disease.- 3 Pathological Diagnosis of Alzheimer's Disease.- 4 The Pathophysiology of Alzheimer's Disease.- 5 Genetic Testing in the Early Diagnosis of Alzheimer's Disease.- 6 Structural Imaging Approaches to Alzheimer's Disease.- 7 Functional Imaging in Alzheimer's Disease.- 8 Neuropsychological Detection of Early Probable Alzheimer's Disease.- 9 Peripheral Markers of Alzheimer's Disease: Directions from the Alzheimer Pathogenic Pathway.- 10 Pupillary Response as a Possible Early Biological Marker for Alzheimer's Disease.- 11 Implications of Early Diagnosis for the Development of Therapeutics for Alzheimer's Disease.- 12 An Ethical Context for Presymptomatic Testing in Alzheimer's Disease.