Klappentext

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition delves into the complexities of drug discovery, specifically for Alzheimer's Disease, presenting the necessary paradigm for future success in research and treatment. This edition is thoroughly updated with recent developments in therapeutic strategies, including amyloid hypothesis, tau, apo E, insulin, and others, and introduces a new chapter on drug delivery to the brain. Additionally, the book encompasses diagnosis, epidemiology, drug discovery strategies, current therapeutics, and more, offering a comprehensive approach to Alzheimer's Disease.

It covers the latest in targeted drug design, preclinical studies, and animal models, making it an essential resource for pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers. Patients and advocacy groups can also gain valuable insights from the overview of current treatments and scientific advancements in the field.

Inhalt

1. Neurodegenerative disorders: why do we need new therapies?
   
   2. Cognitive and functional considerations in Alzheimer’s disease diagnosis
   3. National plan and resources to address Alzheimer’s disease
   4. Biosensor approaches in the diagnosis of a neurodegenerative disorder
   5. Current therapies for the treatment of Alzheimer’s disease: small molecules - Acetylcholine esterase inhibitors and NMDA receptor antagonist
   6. Physicochemical properties for potential AD drugs
   7. Receptor targets in Alzheimer’s disease drug discovery
   8. Amyloid hypothesis in the development of therapeutic agents for Alzheimer’s disease 9: Tau proteins
   9. Cholesterol and fat metabolism in Alzheimer’s disease
   10. Mitochondria as a therapeutic target for the treatment of Alzheimer’s disease
   11. Peptide-based therapeutics
   12. Anti-inflammatory and immunomodulating agents
   13. Prion and other protein folding hypotheses
   14. Simple in vivo models of Alzheimer’s disease
   15. Rodent models for Alzheimer’s disease drug discovery
   16. Drug delivery to the brain
   17. Alzheimer’s disease drugs in clinical trials
   18. Biologics for the treatment of Alzheimer’s disease
   19. Brain health
   20. Non-pharmacologic treatment approaches