This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the central nervous system. HEP 154/I deals with the history of dopamine, the anatomy of dopamine neurons, the biochemistry and molecular biology of dopamine uptake sites and of dopamine receptors.

Klappentext

Dopamine was initially regarded as a mere precursor of noradrenaline, but has progressively gained its present status of a common target for major drug classes and a substrate for some basic functions and dysfunctions of the Central Nervous System. The scientific interest has shifted from typically motor areas of the striatum to traditionally limbic ones as the nucleus accumbens and its afferent areas, the prefrontal cortex, the hippocampal formation and the basolateral amygdala. This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the CNS. - The first volume deals with the history of dopamine, the anatomy of dopamine neurons, the biochemistry and molecular biology of dopamine uptake sites and of dopamine receptors.

Inhalt
1 Brain Dopamine: A Historical Perspective.- A. Introduction.- B. The First Half-Century: 19101959.- C. &The Great Brain Serotonin-Catecholamine Debate.- D. Striatal Dopamine, Parkinsons Disease and Dopamine Replacement.- E. Dopamine Pathways.- F. Experimental Models of Parkinsons Disease.- G. Dopamine Toxins.- H. Dopamine Uptake.- I. Physiology and Pathophysiology of Brain Dopamine.- J. Specific Dopamine Receptors.- K. Direct-Acting Dopamine Agonists.- L. Dopamine and Striatal Neurotransmitter Interactions.- M. Dopamine in Psychiatry.- N. Concluding Remark.- Abbreviations.- References.- 2 Birth of Dopamine: A Cinderella Saga.- A. Introduction.- B. Brodies Breakthrough Discovery, Focusing on Serotonin.- C. Catecholamines Entering the Scene.- D. Discovery of Dopamine.- E. Facing Rejection by Leaders in the Field.- F. New Evidence for Monoaminergic Neurotransmission.- G. A Paradigm Shift: Chemical Transmission in the Brain and Emerging Synaptology.- H. &Awakenings&.- I. Mode of Action of Antipsychotic Agents.- J. Dopamine, the Reward System, and Drug Dependence.- K. Autoreceptors: Discovery and Therapeutic Implications.- L. Concluding Remarks.- References.- 3 The Place of the Dopamine Neurons Within the Organization of the Forebrain.- A. Introduction.- B. The Midbrain and Striatal Circuitry.- C. Connections Between the Midbrain and Cortex.- D. The Amygdala and Other Forebrain Projections.- E. Functional Modulation and Integration Through Dopamine Forebrain Pathways.- References.- 4 Synaptology of Dopamine Neurons.- A. Introduction.- B. Methods for Ultrastructural Labeling of DA Axons.- C. Regional Observations of DA Synaptology.- D. Discussion.- Abbreviations.- References.- 5 D1-Like Dopamine Receptors: Molecular Biology and Pharmacology.- A.Introduction.- B. Molecular Biology of D1-Like Receptors.- C. D1-Like Receptor Pharmacology.- D. Molecular Aspects of Functional Coupling and Signal Transduction for D1-Like Receptors.- E. Distribution of D1-Like Receptors.- F. Pharmacology of D1-Like Receptor-Mediated Function: Behaviour and D1-Like:D2-Like Interactions.- G. Are There Additional D1-Like Receptor Subtypes?.- H. Conclusions.- References.- 6 Understanding the Function of the Dopamine D2 Receptor: A Knockout Animal Approach.- A. Introduction.- B. Transcriptional Regulation of the Dopamine D2 Receptor.- C. Dopamine D2 Receptor Signal Transduction.- D. D2 Receptor Function In Vivo.- E. D2 Receptors Role as an Autoreceptor.- F. D2 Receptor Signaling in Physiology.- G. Neuronal Protective Pathways via the D2 Receptor.- H. Antiproliferative Role of Dopamine in the Pituitary.- I. Genetic Association of the D2 Receptor with Disease.- J. Distinct Functions of the Dopamine D2 Receptor Isoforms.- K. Conclusion.- References.- 7 The Dopamine D3 Receptor and Its Implication in Neuropsychiatric Disorders and Their Treatments.- A. Introduction.- B. Intracellular Signaling of the D3 Receptor.- C. Pre- and Postsynaptic Localizations of the D3 Receptor in the Brain.- D. Coexisting D1 and D3 Receptors in Ventral Striatum Mediate Both Synergistic and Opposite Responses.- E. D1/D3 Receptor Interplay in the Induction and Expression of Behavioral Sensitization: Role of Brain-Derived Neurotrophic Factor.- F. D3 Receptor-Selective Pharmacological Agents.- G. The D3 Receptor and Schizophrenia.- H. The D3 Receptor and Drug Addiction.- I. The D3 Receptor and Depression.- J. Conclusions.- References.- 8 Dopamine D4 Receptors: Molecular Biology and Pharmacology.- A. The Dopamine D4 Receptor.- B. The Multiple Human D4 Receptors.- C.The D4 Receptor Involvement in Schizophrenia.- D. Conclusions.- References.- 9 Signal Transduction by Dopamine D1 Receptors.- A. Historical Perspective.- B. GTP-Binding Proteins Associated with D1-Family Receptors.- C. Adenylyl Cyclases and Phosphodiesterases in the Striatum.- D. cAMP-Dependent Protein Kinase.- E. cAMP-Activated Phosphorylation Pathways.- F. The Role of Protein Phosphatase 1 in the Action of D1 Receptors.- G. DARPP-32.- H. Other Actions of cAMP.- I. Concluding Remarks.- References.- 10 The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics.- A. Introduction.- B. Molecular Biology.- C. Distribution of the Dopamine Transporter.- D. Pharmacology.- E. Genetics Related to the Dopamine Transporter.- Abbreviations.- References.- 11 Cellular Actions of Dopamine.- A. Introduction.- B. DA Receptor Expression in Neostriatal Neurons.- C. Dopaminergic Modulation of Intrinsic Properties of Neostriatal Neurons.- D. D1 Receptor Modulation of Synaptic Transmission and Repetitive Activity in Medium Spiny Neurons.- E. Modulation of Synaptic Transmission by D2-Like Receptors.- F. Dopaminergic Regulation of Corticostriatal Synaptic Plasticity.- G. Summary and Conclusions.- References.- 12 Dopamine and Gene Expression.- A. Introduction.- B. Dopamine Signaling to the Nucleus.- C. Acute Effects of Dopamine on Gene Expression.- D. Chronic Effects of Dopamine on Gene Expression.- References.